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The study aimed to assess the impact of RAS/BRAF mutations on complete response rates after total neoadjuvant therapy (TNT) in advanced rectal cancer patients. Findings revealed that patients with mutant RAS/BRAF had significantly lower rates of achieving clinical and overall complete response compared to those…
A study conducted at a tertiary academic center investigated the correlation between quantitative indocyanine green metrics and subjective indocyanine green perfusion assessment in determining the acceptance or rejection of anastomotic margins. The study included 89 perfusion assessments in 156 intestinal segments. The results showed that…
A study compared different techniques for reducing recurrence rates after endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps. The direct and indirect comparisons showed that EMR combined with submucosal tunneling endoscopic submucosal dissection (EMR+STSC) and underwater EMR (U-EMR) had significantly lower odds of polyp…
Disparities in colon cancer care and outcomes exist based on race/ethnicity, socioeconomic status (SES), and insurance. Low-performing hospitals treat more non-Hispanic black, Hispanic, low SES, and Medicaid patients. Patients with low SES and Medicaid have decreased odds of receiving high-quality care at low-performing hospitals, while…
In a retrospective cohort study, researchers evaluated the mid-term outcomes of indocyanine green fluorescence imaging-guided laparoscopic right-sided colectomy. After propensity score matching, they found that the number of dissected central, intermediate, and total lymph nodes was significantly higher in the indocyanine green group. However, there…
A retrospective multicenter study compared the risk of distant metastases in rectal cancer patients who achieved a clinical complete response followed by local regrowth with those managed by surgery after chemoradiation. Out of 79 patients with local regrowth, 21 developed distant metastases, whereas only 10…
Rectal stump leakage is a significant complication after discontinuity resection, with a rate of 11.78% in this study. The risk varies depending on the surgical procedure, and it was highest after subtotal pelvic exenteration. Researchers found that a shorter rectal stump, previous pelvic radiotherapy, chemotherapy,…
The study examined 68 surgical resections from patients with small bowel adenocarcinoma (SBA) to investigate the correlation between immunophenotypes, DNA mismatch repair status, genomic profiling, and clinicopathologic characteristics. The results showed that the expression of certain proteins correlated with tumor location, histologic type, and TNM…
The study investigated the rate of proctectomy and rectal cancer among 197 familial adenomatous polyposis (FAP) patients selected for total abdominal colectomy with ileorectal anastomosis. The results showed that the incidence of proctectomy was 8%, with rectal cancer identified in 3% of cases. Patients with…
Implementation of a multimodal prehabilitation program in colorectal surgery reduces postoperative complication rates, length of stay, and hospital costs. A study conducted in a regional Dutch hospital included 196 patients who completed prehabilitation and 390 patients who received standard care. The prehabilitation group had lower…
