The intersphincteric complex serves as a metastasis niche in ultralow rectal cancer, with 30.96% of patients showing tumor presence in this area. Complete excision of the complex correlates with significantly improved disease-free survival and local recurrence-free survival rates (HR, 0.382; p=0.008 and HR, 0.251; p=0.012, respectively). These findings emphasize the anatomical and prognostic importance of […]
Category: Intestine and Lower Gastrointestinal Tract
Prophylactic clipping is cost-saving after endoscopic mucosal resection.
A cost-effectiveness analysis involving 4,557 patients found that prophylactic clipping (PC) during endoscopic mucosal resection (EMR) of large non-pedunculated colon polyps is beneficial. For a typical 65-year-old undergoing EMR, PC yielded an incremental cost-effectiveness ratio (ICER) of -$154,706. It proved cost-effective for very large polyps (≥40 mm) and cost-saving for patients on antithrombotic therapy when […]
CPLX2 and SNAP25 genes are key in colorectal cancer liver metastasis
CPLX2 and SNAP25 have been identified as significant players in the progression of colorectal cancer liver metastasis. Researchers discovered that these genes are overexpressed in metastatic tissues compared to primary tumors. They also noted that these genes positively regulate the phosphatidylinositol 3-kinase-AKT signaling pathway. Through comprehensive analyses of gene expression and immune infiltration, 1,215 differentially […]
Salvage ESD proves effective for previously attempted colorectal lesions
Salvage endoscopic submucosal dissection (ESD) for previously attempted colorectal lesions demonstrated an en bloc rate of 83.4% and curative resection in 73.5% of cases. Among 415 lesions treated, adverse events occurred in 11.8% of patients, with the most frequent being intraprocedural perforation. Notably, there were no procedure-related mortalities. With expert execution, salvage ESD shows high […]
Laser-endoscopic therapy shows effective early outcomes for pilonidal sinus
A combined approach of SiLaC® and EPSiT® for pilonidal sinus disease demonstrated promising results in a study involving 83 patients. The mean operative time was 25 minutes, with a low postoperative pain score of 1.2. Most patients (92.3%) returned to normal activities within 24 hours, and 95% achieved complete healing within three weeks. The recurrence […]
Enhanced hemorrhoidectomy technique shows improved outcomes
A combination of Milligan-Morgan hemorrhoidectomy with rubber band ligation and polidocanol foam sclerotherapy significantly lowers recurrence rates and enhances patient satisfaction compared to traditional hemorrhoidectomy. In a study involving 255 patients, the MMH + RBL + PFS group evidenced a recurrence rate of just 0.78%, versus 7.09% with standard MMH, while achieving higher satisfaction scores (91.41% vs. 81.10%). Additionally, […]
Genetic profiling predicts chemotherapy response in colorectal liver metastasis
A study involving 230 Chinese patients with colorectal liver metastasis identified significant predictors for chemotherapy response. Key factors included gender, the use of biological targeted agents (BTAs), and specific mutations in the KRAS gene and other rare genes. A predictive model achieved an area under the curve (AUC) of 0.73, indicating that around 75% of […]
KRAS status impacts surgical outcomes for colorectal liver metastases
A study involving 220 patients revealed that KRAS mutations negatively affect long-term outcomes after thermal ablation (TA) and liver resection (LR) for colorectal liver metastases (CRLM). Among patients with mutated KRAS, factors like synchronous disease and the performance of multiple TAs significantly influenced disease-free survival. Furthermore, while TA was associated with liver-only recurrences in both […]
Nomogram effectively predicts lymph node metastasis in colon cancer
An innovative online nomogram has been developed to predict the risk of lymph node metastasis (LNM) in colon cancer patients, enhancing treatment decision-making. Built on data from 412 patients, the model identified eight key independent predictors, demonstrating high discriminative ability with AUCs of 0.834 and 0.872 in training and validation cohorts, respectively. This tool presents […]
Intracorporeal anastomosis significantly reduces incisional hernia rates.
A study of 192 patients undergoing laparoscopic right colectomy revealed that intracorporeal anastomosis is associated with a significantly lower incidence of incisional hernia compared to extracorporeal anastomosis. Notably, no incisional hernias occurred at the minilaparotomy site in the intracorporeal group, while 13.3% of extracorporeal patients developed one. The intracorporeal approach also correlated with a shorter […]