Patients with rectal cancer who undergo total neoadjuvant therapy have significantly worse survival rates after liver surgery. Median overall survival is 48.7 months for total neoadjuvant therapy patients vs 99.5 months for those who didn’t (p = .01). Total neoadjuvant therapy is an independent predictor of decreased overall survival (hazard ratio 0.41). Watch for higher […]

A new predictive score identifies patients at risk for perineural invasion (PNI) in colorectal cancer, impacting surgical management and outcomes. PNI was found in 13.1% of patients; it predicts a 5-year overall survival of 54% versus 76.4% without PNI. Key predictors include age, male sex, race, tumor location, histology, and elevated carcinoembryonic antigen (CEA) levels. […]

Patients with cT4 tumors show significantly lower chances of achieving a complete clinical response (cCR) compared to those with cT3. Overall cCR rate was 32.8%: 38% for cT3, 23% for cT4 (p = 0.09). cT4 disease reduced odds of cCR by 69% (odds ratio 0.31; 95% CI 0.11-0.88). Surgeons should consider tumor stage when counseling […]

Diverting ileostomy significantly reduces the risk of anastomotic leakage during colorectal cancer surgery, but specific risk factors can complicate outcomes. Anastomotic leakage occurred in 17.5% of patients, with lower rectal tumors as the sole significant risk factor (p=0.0095). Reoperation due to leakage was necessary for 19% of these cases, particularly in patients with T4 tumors […]

Laparoscopy, robotic-assisted, and transanal techniques showed mixed success in high-risk rectal cancer patients, all falling short of expected outcomes. Primary outcome rates: 82.4% (laparoscopy), 64.3% (laparotomy), 74.7% (robotic), and 80.3% (transanal). 96% R0 resection rate across all techniques; no significant difference found. Conversion rates for minimally invasive methods remained consistent at 4.5%. Surgeons should consider […]

Watch-and-wait may be an option for rectal cancer patients, but specific conditions must be met to avoid worse outcomes. Salvage rates below 75% threaten disease-free survival; rates must stay above this for safety. Ten-year overall survival rates are similar: 83.0% for watch-and-wait vs. 81.5% for surgery. Monitoring regrowth rates is essential; if it exceeds 10% […]

Surgeons should note that inflammatory bowel disease (IBD) is frequently diagnosed following a positive faecal immunochemical test (FIT), particularly in patients under 50. 2.3% of patients with FIT ≥10 µg Hb/g were diagnosed with IBD; this drops to 0.1% with lower levels. Among patients under 50 with elevated FIT and faecal calprotectin (FCP), the IBD […]