The overview of systematic reviews indicates that stem cell therapy significantly improves clinical remission and fistula closure rates. The relative risk for clinical remission was 1.299, and for short- and long-term closure rates, it was 1.481 and 1.422, respectively. Importantly, safety analysis revealed no significant increase in adverse events, suggesting a favorable safety profile. The […]
Category: Intestine and Lower Gastrointestinal Tract
Double-balloon platform significantly reduces colorectal ESD procedure time
A randomized controlled trial demonstrated that the double-balloon interventional platform (DBIP) markedly reduced mean procedure time for colorectal endoscopic submucosal dissection (ESD) to 88.6 minutes, compared to 139.5 minutes for traditional ESD—a 36.5% reduction. Additionally, DBIP-assisted ESD improved en-bloc resection rates and sutured defect closures while saving $610.16 per patient, indicating its effectiveness and cost […]
Deep learning accurately classifies colorectal liver metastasis growth patterns
A new deep learning algorithm successfully distinguishes between desmoplastic and non-desmoplastic histopathological growth patterns in colorectal liver metastases, achieving high discriminatory power with area under the curve values of 0.93 and 0.95 during development and external validation, respectively. This automated classification parallels manual scoring regarding overall survival outcomes, ensuring its potential utility in routine histopathological […]
Colonoscopy significantly reduces colorectal cancer incidence
In a retrospective analysis of colorectal cancer (CRC) patients, researchers found a strong link between colonoscopy screenings and reduced CRC incidence. Despite the increase of early-onset CRC among individuals under 50, no correlation was observed between familial cancer history and CRC incidence. Alarmingly, delays of up to six years were noted between initial symptoms and […]
Specific risk factors identified for suicide in colorectal cancer patients
A study analyzed 309,561 colorectal cancer patients, revealing that male sex, non-Hispanic ethnicity, low income, and metastatic disease significantly increase suicide risk. The suicide rate decreased from 1% in 2000-2010 to 0.05% in 2011-2020. Among those diagnosed in the latter period, the risk of suicide reduced substantially. The findings suggest that targeted screening for suicidality […]
Recognition of Borderline Resectable Colorectal Liver Metastases as a Distinct Entity
The review delineates ‘borderline resectable colorectal liver metastases’ (BR-CRLM) as a distinct category, integrating both surgical and oncological criteria for optimal decision-making. Current treatments highlight the necessity of pre-operative chemotherapy and advanced surgical interventions, which now offer substantial long-term survival benefits. By emphasizing this classification, clinicians can better tailor therapeutic strategies, involving locoregional therapies and […]
Stable fecal diversion rates noted in ulcerative colitis surgeries
Population-level data indicates that the rate of diverting ileostomy creation during ileal pouch-anal anastomosis for adults with ulcerative colitis has remained consistent from 2000 to 2019. A comparison between the diverting ileostomy cohort and those without revealed longer hospital stays for the latter group, yet a decline in readmission rates was observed. Regional variations in […]
Robotic surgery reduces ejaculatory dysfunction after rectal cancer procedures
Post-operative assessments revealed that 34.7% of patients experienced erectile dysfunction (ED) and 29.8% faced ejaculatory dysfunction (EJD) a year after minimally invasive rectal cancer surgeries. Notably, patients undergoing robotic surgery reported a significantly lower EJD rate of 25.0% compared to 40.9% for laparoscopic surgery, with less potency impairment at 6 and 12 months. These findings […]
Specialized colorectal surgeons improve outcomes in emergency surgeries
Emergency colorectal surgeries performed by specialized colorectal surgeons lead to significantly lower 30-day and in-hospital mortality rates (30-day mortality odds ratio 0.64; p < 0.0001). These specialists also demonstrate higher rates of primary anastomosis (odds ratio 2.95; p < 0.0001) and laparoscopic procedures (odds ratio 2.38; p = 0.001), paired with a reduced likelihood of […]
Psychiatric disorders increase complications after IBD surgery
In a study of 81,955 patients undergoing surgery for inflammatory bowel disease (IBD), 26.6% were identified with psychiatric disorders (PDs). These patients faced significantly higher risks of postoperative ileus, longer hospital stays, and increased costs. Furthermore, they had higher odds of non-home discharge and 30-day readmissions. The prevalence of PDs among IBD patients rose from […]