A study involving 169,498 Medicare patients revealed that those living in areas of high social vulnerability had significantly worse perioperative outcomes after colectomy for colon cancer. Patients in the highest social vulnerability quintile were 1.36 times more likely to require unplanned surgeries and faced higher 30-day and 1-year mortality rates compared to those in the […]
Category: Intestine and Lower Gastrointestinal Tract
Preoperative inflammatory burden index predicts colorectal cancer outcomes.
A study of 555 colorectal cancer patients found that the preoperative inflammatory burden index (IBI) is a significant predictor of both surgical and oncological outcomes. Higher IBI scores correlate with advanced disease stages and poorer disease-free and overall survival rates, particularly in high-risk stage II and III patients. Additionally, elevated IBI increased the likelihood of […]
ERAS protocols significantly shorten hospital stays after colorectal surgery
Implementation of enhanced recovery after surgery (ERAS) protocols at 15 Ontario hospitals resulted in a significant 1.05-day reduction in length of stay (13.7%) for colorectal surgeries. Notably, left-sided colorectal surgeries saw an even greater decrease of 1.17 days (15.6%). This reduction remained consistent over time and was more pronounced after adjusting for various predictors. The […]
Stool-based surveillance reduces colonoscopies after polypectomy
Stool-based surveillance strategies may safely decrease colonoscopy demand by 15-41% following polypectomy, according to the MOCCAS study. Conducted on 3,453 individuals, the study demonstrated that multitarget stool DNA tests and fecal immunochemical tests (FIT) were effective alternatives, especially for those at lower risk. Long-term simulations indicated that while multitarget stool DNA testing incurred higher costs, […]
GAME-SCORE predicts chemotherapy response in colorectal liver metastases
GAME-SCORE demonstrates predictive value for pathological and radiological responses to neoadjuvant chemotherapy in colorectal liver metastases. High-risk GAME-SCORE patients exhibited significantly lower pathological response rates (82.6%) and increased radiological progression (10%) compared to low (3.8%) and moderate (3.5%) risk groups. Furthermore, multivariable analysis identified high-risk GAME-SCORE as an independent predictor of pathological response, alongside factors […]
Positive circumferential resection margin linked to recurrence in rectal cancer
A study analyzed 682 patients with locally advanced rectal cancer, revealing that 6.9% experienced local recurrence post-neoadjuvant chemoradiotherapy and total mesorectal excision. Key risk factors identified included positive circumferential resection margin, venous invasion, and perineural invasion. Among those with recurrence, 53.2% were resectable, and 65.2% of those who underwent curative resection achieved R0 status. Superior […]
CALLY index predicts surgical complications in obstructive colorectal cancer
The C-reactive protein-albumin-lymphocyte (CALLY) index effectively predicts postoperative complications for patients with obstructive colorectal cancer undergoing colonic stenting. In a study of 263 patients, those with a low CALLY index experienced significantly higher blood loss, poorer performance status, and increased complications compared to those with a high index. Multivariate analysis revealed prolonged operative time, greater […]
Eight-zone dissection improves outcomes in rectal cancer surgery
An innovative eight-zone laparoscopic dissection strategy significantly enhances postoperative specimen integrity and reduces nerve injury risk compared to traditional techniques in rectal cancer surgery. Among 218 patients analyzed, those undergoing the eight-zone approach demonstrated an 88.1% integrity rate in surgical specimens and improved preservation of urinary and sexual functions. This study underscores the effectiveness and […]
Advanced endoscopic techniques improve colorectal polyp treatment outcomes
Advanced endoscopic resection techniques significantly enhance treatment for colorectal polyps, achieving higher en bloc resection rates compared to traditional methods. En bloc resection rates for endoscopic mucosal resection (EMR) range from 44.5% to 63%, while endoscopic submucosal dissection (ESD) boasts rates between 87.9% and 96%. ESD is effective for larger polyps and certain carcinomas, with […]
Preoperative inflammation scores predict postoperative complications in colorectal surgery
Key results indicate that preoperative systemic inflammatory markers and scoring systems significantly impact early postoperative complications and mortality in colorectal cancer patients. Specifically, neoadjuvant chemoradiotherapy and various prognostic scores, including the modified Glasgow prognostic score and the prognostic nutritional index, were linked with 30-day mortality (p < 0.001 for several measures). These findings underscore the […]