Circulating tumor DNA (ctDNA) shows promise as a prognostic biomarker in locally advanced rectal cancer (LARC), with meta-analysis revealing a significantly increased risk of recurrence in post-neoadjuvant and post-operative periods for ctDNA-positive patients. This systematic review underscores the value of ctDNA in identifying LARC patients at higher risk of disease recurrence, providing insights into disease […]
Category: Intestine and Lower Gastrointestinal Tract
GLR as an Independent Prognostic Marker in Colorectal Cancers
Preoperative glucose/lymphocyte ratio (GLR) in colorectal cancers independently predicts prognosis. Analysis of 222 patients showed high GLR (≥3.04) correlated with increased mortality (p=0.001) and lower overall survival rates. GLR levels (p≤0.001) significantly related to age, perineural invasion, tumor grade, TNM stage, and surgery time. GLR ≥3.04 raised mortality risk 2.9 times (p=0.003). GLR could aid […]
Improved Outcomes with Robotic and Transanal Total Mesorectal Excision
Robotic total mesorectal excision (TME) and transanal TME showed better postoperative results compared to laparoscopic TME in locally advanced rectal cancer patients. Robotic TME had lower rates of anastomotic leakage and open surgery conversions, while transanal TME had shorter hospital stays and time to flatus. No significant differences were observed in operating time, complications, blood […]
Filgotinib 200 mg Shows Efficacy in Perianal Fistulising Crohn’s Disease
Filgotinib 200 mg demonstrated efficacy in treating perianal fistulising Crohn’s disease, with a higher proportion of participants achieving a combined fistula response compared to lower doses and placebo. Serious adverse events were more frequent with the 200 mg dose, but no treatment-related serious adverse events or deaths were reported. Filgotinib 200 mg was generally well […]
High Rates of Colitis-Associated Post-Colonoscopy Colorectal Cancers
Analysis reveals 61% of inflammatory bowel disease-related colorectal cancers were post-colonoscopy, often due to delays in surveillance and missed lesions in areas of inflammation. Proactive strategies are needed to reduce endoscopic burden and improve surveillance adherence, as traditional methods show limitations in detecting aggressive cancer evolution. Molecular biomarkers may enhance risk assessment in future clinical […]
Experimental Ostomy Device for Parastomal Hernia Prevention
An innovative ostomy protector, in conjunction with a compression binder, was proven safe and effective in reducing parastomal hernia in ostomates. With a low incidence of hernia-related complications, patients reported high satisfaction levels with the prototype, signifying its potential clinical value as a preventive measure. Collaborative design efforts between healthcare professionals and end-users yielded a […]
Similar Long-Term Survival in MIS for Ileal NETs
Minimally invasive surgery (MIS) shows comparable long-term survival outcomes to open surgery for ileal neuroendocrine tumors (i-NETs), with no significant difference in overall survival rates at around 99 to 103 months follow-up. MIS is a viable alternative for i-NETs resection, especially in cases without bulky mesenteric masses or concurrent liver resections. The study suggests MIS […]
Neoadjuvant Immunotherapy Safe for Rectal Cancer Surgery
Neoadjuvant immunotherapy for rectal cancer does not worsen surgical outcomes. A retrospective study of 26,229 patients showed no significant differences in length of stay, readmission, or mortality between those who received immunotherapy and those who did not. This suggests that adding immunotherapy to standard treatment protocols does not increase postoperative complications, offering clinicians valuable insights […]
Accuracy of 3D-Printed Anatomical Models for Perianal Fistulas Assessment
3D-printed anatomical models accurately reflect MRI findings of perianal fistulas, showing almost perfect agreement for classification, substantial agreement for complexity and location, and moderate agreement for sphincter involvement. Further research is needed to assess the clinical utility of these models in preoperative planning and education. The study demonstrates the potential of 3D-printed models to enhance […]
Laser Hemorrhoidoplasty Outperforms Rubber Band Ligation
Laser hemorrhoidoplasty demonstrated superior clinical efficacy over rubber band ligation in treating grade II hemorrhoids, with significantly improved postoperative pain, bleeding, and anal distension within 2 weeks. Both methods effectively relieved symptoms, with no difference in recurrence rates at 1 year post-surgery. Patients undergoing laser hemorrhoidoplasty also had faster recovery times, making it an ideal […]