Moabp significantly reduced overall postoperative complications, surgical site infections (SSIs), and anastomotic dehiscences in patients undergoing elective rectal resection compared to those receiving mechanical bowel preparation (MBP) plus a placebo. Patients in the Moabp group had lower rates of complications and SSIs, highlighting the potential of Moabp as a standard treatment in reducing morbidity after […]
Category: Intestine and Lower Gastrointestinal Tract
Survival Benefits of Hepatic Artery Therapies in Colorectal Liver Metastases
Systematic review and meta-analysis of hepatic artery-based therapies and systemic chemotherapy for unresectable colorectal liver metastases showed high overall survival rates for hepatic artery infusion and favorable outcomes compared to doublet chemotherapy in specific subgroups. Triplet chemotherapy had the best outcomes but with higher toxicity and inclusion of potentially resectable patients. The upcoming EA2222 pump […]
Low Rates of Colorectal Cancer Screening in First-Degree Relatives of Patients with Early-Onset Colorectal Cancer
First-degree relatives of patients with early-onset colorectal cancer have low rates of colorectal cancer screening, with only 44% undergoing screening despite guidelines recommending screening starting at age 40 or 10 years before the age of their relative’s diagnosis. Factors such as race, stage of disease, insurance coverage, and location were associated with lower screening rates, […]
Pathologic Response Predicts Rectal Cancer Survival
Rectal cancer patients who achieved pathologic complete response after neoadjuvant therapy had improved survival compared to those with residual carcinoma in situ. Factors associated with decreased survival included older age, higher comorbidity score, and poorly differentiated tumors, while factors linked to improved survival were female gender, private insurance, and receiving both neoadjuvant and adjuvant chemotherapy. […]
Robotic colectomy reduces postoperative morbidity and mortality compared to laparoscopic colectomy
Significantly lower rates of postoperative morbidity, mortality, and postoperative ileus were observed in robotic colectomy compared to laparoscopic colectomy. However, robotic approach was associated with longer operative times, though with shorter hospital stays. No significant difference was found in anastomotic leak rates. This study provides evidence supporting the benefits of robotic colectomy in minimizing postoperative […]
Increased Relative Risk of Cancer in Patients with Diverticular Disease
Patients with diverticular disease had an increased long-term relative risk of cancer, excluding colorectal cancer, possibly due to shared risk factors. The highest standardized incidence ratios were for lung, bronchi, trachea, and kidney cancers. The decreased risk of colorectal cancer may be due to increased colonoscopy rates in diverticular disease patients, potentially leading to early […]
Extreme gradient boost machine learning model accurately predicts mortality risk in primary appendiceal cancer patients
Researchers developed a novel machine learning algorithm using extreme gradient boost to predict 1-, 5-, and 10-year mortality risk in patients with primary appendiceal cancer. The model exhibited high prediction accuracy, with a maximum area under the curve of 0.909 for the 10-year model. Variables such as disease grade, histology, lymph node involvement, and distant […]
Prognostic Factors for Liver Metastasis in Small Intestinal Stromal Tumors
Researchers analyzed data from 1582 patients with small intestinal stromal tumors to identify risk factors for liver metastasis. They found that poor tumor grade, absence of surgery, later T-stage, and no chemotherapy were associated with an increased risk of liver metastasis. A nomogram prediction model showed good performance in predicting liver metastasis, and patients with […]
Histological Growth Pattern Predicts Survival in Peritoneal Metastases
Patients with colorectal peritoneal metastases who underwent cytoreductive surgery had better disease-free and overall survival if they had a dominant pushing histological growth pattern compared to infiltrating pattern. The study confirmed the prognostic value of these patterns regardless of neoadjuvant chemotherapy or extent of peritoneal disease burden. No significant associations were found between neoadjuvant chemotherapy […]
Similar Outcomes of Anastomosis vs. Colostomy After Sigmoid Colectomy for Volvolus
Outcomes between primary anastomosis and end colostomy following emergency sigmoid colectomy for sigmoid volvulus were compared using ACS-NSQIP data. Results showed no significant differences in major complications, mortality, hospital stay, or readmission rate. Patients with colostomy had a higher likelihood of being discharged to a care facility. Overall, there were no statistically significant disparities in […]