The OPAXX study aims to determine the rate of successful organ preservation in patients with rectal cancer who have a good clinical response after neoadjuvant therapy. The study, conducted in the Netherlands, will include 168 patients who will be randomized into two parallel single-arm phase II studies. Study arm 1 will evaluate the effectiveness of […]
Category: Intestine and Lower Gastrointestinal Tract
Laparoscopic Approaches Have Lower Complication Rates in Oncological Right Hemicolectomy Comparison
In a study comparing open surgery, laparoscopy with intracorporeal anastomosis, and laparoscopy with extracorporeal anastomosis for oncological right hemicolectomy, researchers found that laparoscopic approaches had significantly lower complication rates than open surgery. The duration of surgery was longer in the laparoscopic groups, but the length of hospital stay was shorter. Reoperation within 30 days only […]
Predictive Factors for Early Recurrence in Metastatic Colorectal Cancer Treated with Combined Liver Resection and HIPEC
The study aimed to identify predictive factors for early recurrence and survival outcomes in colorectal cancer patients with liver and peritoneal metastases who underwent combined liver resection, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy. The results showed that patients with advanced primary tumors (PT4 and/or PN2 status) had a higher risk of early recurrence, while retroperitoneal […]
Increased Mortality and Complications Associated with Care Fragmentation in Ileostomy Patients
A study analyzing hospitalizations for ileostomy creation found that care fragmentation, defined as receiving care at a different facility than where the index ileostomy was performed, was associated with higher mortality rates and increased risk of postoperative complications such as cardiac, respiratory, infectious, and thromboembolic complications. Patients experiencing care fragmentation also had higher hospitalization costs. […]
Distinct Trajectories of Quality of Life Following Pelvic Exenteration for Advanced Cancers
Results from a prospective cohort study conducted at a highly specialized pelvic exenteration referral center revealed distinct trajectories of quality of life following surgery for advanced cancers within the pelvis. Two trajectory classes were identified for physical component score, three for mental component score, and three for functional assessment of cancer therapy-colorectal total score. Patients […]
Direct Tumor Involvement in Resection Margin Signals Worse Prognosis in Rectal Cancer
Rectal cancer patients with a positive circumferential resection margin (CRM) due to direct tumor involvement face a worse prognosis than those with indirect causes. Analyzing 1460 cases, 85 had positive CRMs, with direct involvement linked to increased local recurrence. Kaplan-Meier analysis showed better overall and disease-free survival in indirect cases. The study emphasizes the need […]
Characterization of Colorectal Carcinoma With Sarcomatoid Components and Suggestions for Differentiation
Colorectal carcinoma with sarcomatoid components is a rare and aggressive subtype of colorectal cancer. In this study, researchers reported 15 cases of this subtype and reviewed the existing literature. The tumors were predominantly found in the rectosigmoid region and presented with symptoms such as abdominal pain and gastrointestinal bleeding. The sarcomatoid component of the tumors […]
Precision Surgery Shows Promising Results for Colorectal Liver Metastases Patients with Mutras Tumors
The systematic review and meta-analysis of studies investigating the association of surgical technique with outcomes for colorectal liver metastases (crlm) found that anatomic resection (AR) was associated with improved liver-specific disease-free survival (DFS) and overall DFS in patients with mutras tumors. Specifically, AR resulted in a 40% improvement in liver-specific DFS and a 28% improvement […]
Improved Surgical Outcomes for Female Surgeons in Predominantly Female Patient Surgeries
Preliminary evidence from a retrospective study using the New York State SPARCS database suggests that female surgeons have better post-operative outcomes than their male colleagues in predominantly female patient surgeries. The study examined the impact of patient-surgeon gender discordance on outcomes in bariatric, foregut, and colorectal surgeries. The results showed that patient-surgeon concordance had a […]
Practical Recommendations for Pouchitis Management by AGA
The AGA Clinical Practice Guideline on the Management of Pouchitis and Inflammatory Pouch Disorders provides practitioners with recommendations for the prevention and treatment of pouchitis, Crohn’s-like disease of the pouch, and cuffitis. The guideline panel made 9 conditional recommendations, including the use of antibiotics for intermittent pouchitis, probiotics for recurrent pouchitis, and advanced immunosuppressive therapies […]