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A tailored diagnostic protocol using contrast-enhanced computed tomography enterography and 68 Ga dotatate PET/CT showed high sensitivity and specificity in detecting primary small intestinal neuroendocrine tumors (SI-NETs) and distal lymph node disease. The combined imaging allowed for the identification of low-risk surgical candidates with single SI-NET…
Gallbladder neuroendocrine neoplasms (GB NENs) are predominantly represented by neuroendocrine carcinomas. Outcomes analysis of 147 patients revealed a median overall survival (OS) of 6.14 months, with significant improvement to 20.20 months for those who received multimodality treatment versus 4.00 months for those who did not.…
Prone Jack-Knife Transanal Minimally Invasive Surgery (tamis) is a feasible and safe approach for managing subepithelial rectal lesions, specifically anterior low rectal gastrointestinal stromal tumors (gist). This surgical technique, performed with the patient in the prone jack-knife position and using transanal access, provides excellent surgical…
The study investigated the factors associated with offering surgery for pancreatic and small bowel neuroendocrine neoplasms (pannen and sbnen). Analysis of the surveillance databases revealed that non-white race was associated with decreased odds of surgery offer for sbnen but not pannen. These findings highlight racial/ethnic…
Implementing advancements in technology and surgical technique for internal hemipelvectomy procedures can significantly impact patient outcomes. A retrospective study conducted at a single institution examined the experiences of surgeons and the utilization of new techniques and technologies over a 26-year period. The study found that…
Researchers analyzed a large number of tissue samples and found that gad2 immunohistochemistry is a highly specific diagnostic marker for neuroendocrine neoplasms of the pancreas. The expression of gad2 was only observed in a few normal cell types, making it a potential diagnostic tool. It…
Portal vein resection in surgery for pancreatic neuroendocrine neoplasms was analyzed in this study. Among 666 patients, 8% underwent portal vein resection. Postoperative complications were comparable to standard resection, with a low 90-day mortality rate. Radical resection resulted in excellent 5-year overall and disease-specific survival…
Researchers conducted a study to develop and validate a nomogram for predicting overall survival (OS) in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Using data from the SEER registry, they identified key prognostic factors and compared the nomogram's performance to the AJCC staging system. The results…
Netosis, the formation of neutrophil extracellular traps (NETs), is a novel function of neutrophils. These NETs play a crucial role in trapping microorganisms and preventing their spread throughout the body. However, they can also lead to tissue damage and contribute to various diseases like gallstone…
A retrospective study compared minimally invasive (MIS) and open surgery for treating small intestinal neuroendocrine neoplasms. Out of 65 patients, 54% underwent MIS and 46% underwent open surgery. The study found no significant difference in the frequency of successful resections or the number of lymph…
