Newsletter
Best Papers in General Surgery
The five that matter, every day.
A nationwide survey revealed that 67.14% of Italian endocrine surgeons now routinely employ intraoperative nerve monitoring (IONM) during thyroid and parathyroid surgeries. This marks a significant increase since 2014, indicating improved surgical safety and reduced complication rates. Despite growing acceptance, challenges such as the variability…
In a cohort study of 251 patients with pancreatic ductal adenocarcinoma, neoadjuvant therapy followed by surgical resection significantly improved overall survival (39.87 months vs. 18.86 months) and recurrence-free survival (25.67 months vs. 12.83 months) compared to upfront surgery. Elevated carcinoembryonic antigen (CEA) levels were linked…
Carboxypeptidase z (cpz) demonstrates significant diagnostic potential for differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC). The study found cpz expressed in 90.8% of HCC cases, compared to 27.7% in ICC. Diagnostic accuracy was enhanced when cpz was combined with arginase-1 and hepatocyte paraffin antigen-1.…
A study of 1196 acute appendicitis patients revealed that 38.9% had complicated cases. Key predictive factors include male gender, age, duration of abdominal pain, temperature, abdominal tension, neutrophil count, and the presence of appendiceal fecaliths. The research developed a predictive nomogram that aids clinicians in…
Standardized electronic order sets significantly decreased inpatient opioid use for emergency general surgery patients from January 2019 to June 2023. The total morphine milligram equivalents (mme) per patient and average mme per opioid dose decreased notably, demonstrating sustained effects across administration routes. Additionally, lower mme…
A systematic review and meta-analysis revealed that circular skin closure (CSC) markedly decreases the rate of surgical site infections (SSI) following stoma closure compared to primary sutures (PS). Researchers found that only 4% of patients using CSC developed SSI, in contrast to 27% in the…
A novel risk-stratification model for statistical cure after hepatectomy in hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) reveals an overall cure probability of 21.2%. The study identified eight independent risk factors, including high viral load and macrovascular invasion, that significantly influence outcomes. Low-risk patients achieved a…
A multimodal prehabilitation regimen improved postoperative outcomes for patients undergoing esophagogastric cancer surgery. Of 94 participants analyzed, those who completed at least 2 weeks of structured prehabilitation showcased a significant reduction in postoperative pneumonia compared to the control group. This research underscores the importance of…
The CARES trial aims to determine the effectiveness and safety of analgesic regimens in postoperative pain management. Enrolling adults undergoing elective surgeries, participants are randomized to receive either NSAIDs or low-dose opioids, complemented by acetaminophen. The primary outcomes include patient-reported pain intensity and side effects…
A systematic review involving 1,002 patients revealed that extraperitoneal colostomy (EPC) significantly lowers the incidence of parastomal hernia compared to transperitoneal colostomy (TPC) after laparoscopic abdominoperineal resection for rectal cancer. The EPC technique also showed reduced rates of stoma retraction, prolapse, and overall stoma-related complications.…
