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Best Papers in General Surgery
The five that matter, every day.
Long-term oncological outcomes of single-port laparoscopic hepatectomy for hepatocellular carcinoma were compared with multiport laparoscopic hepatectomy. Recurrence rates were higher in the splh group, but overall and recurrence-free survival did not significantly differ between groups. Splh method and portal vein invasion were identified as independent…
Overlap anastomosis showed superior outcomes compared to functional end-to-end anastomosis in laparoscopic colorectal cancer surgery, with shorter operation and recovery times and lower post-operative complication rates. These findings suggest that overlapping anastomosis can expedite intestinal function recovery without compromising patient quality of life or survival…
Pre-operative biliary drainage significantly raised complication rates in periampullary lesion patients, as shown by a meta-analysis including 35 studies and 2 randomized trials with 12,641 patients. Results revealed higher overall complication rates, increased delayed gastric emptying post-surgery, and a significant rise in wound infections post-operatively…
A novel bile-based assay, BileMet, distinguishes biliary tract cancer (BTC) from benign diseases with high accuracy (AUC 0.891). It identifies 6 metabolite biomarkers, including chenodeoxycholic acid glycine conjugate, associated with BTC. BileMet offers rapid intraoperative testing, surpassing limitations of current diagnostic methods like brush cytology,…
Identifiable tumor mutational burden (TMB) in post-operative circulating tumor DNA predicts recurrence in hepatocellular carcinoma patients. TMB detection, unlike AFP, showed significant association with reduced recurrence-free survival and higher recurrence rates. TMB outperformed AFP in predicting post-operative recurrence, with a cut-off of 4.8 mutations/megabase. CTDNA…
Patient-derived organoids (PDOs) from EUS-guided biopsies show high success rate in establishing models for pancreatic ductal adenocarcinoma (PDAC). PDAC PDOs accurately reflect genetic alterations in the original tumors and predict drug sensitivity, including resistance to nab-paclitaxel. This innovative model enables rapid testing of multiple therapeutic…
Polymerase chain reaction accurately detects bacteria in peritoneal fluid, guiding postoperative antibiotic treatment in patients with acute appendicitis. Results show concordance of 71.4% between PCR and conventional culture, with Escherichia coli and Bacteroides fragilis being the most common bacteria. Study highlights PCR's potential in diagnosing…
This study developed and validated a new lymph nodal staging system for pt3-4n0-2m0 gastric cancer patients. The new classification, based on examined lymph nodes and lymph node ratio, outperformed the current system in prognostic prediction accuracy. The improved staging method emerged as an independent prognostic…
Total pancreatectomy with islet autotransplantation (TPIAT) provides beneficial metabolic and pain relief outcomes in patients with genetic chronic pancreatitis. Patients with genetic etiology undergo TPIAT at a younger age, experience longer symptom duration, and yield lower islet mass, yet maintain similar metabolic function post-transplant. Post-TPIAT,…
Subcutaneous fat thickness (TSF) is linked to higher postoperative seroma risk following laparoscopic hernioplasty. In a study of 229 male patients, factors like longer hernia duration, larger defects, and TSF ≥26.0 mm were associated with increased seroma risk. TSF ≥26.0 mm had an odds ratio…
