Newsletter
Best Papers in General Surgery
The five that matter, every day.
Gut microbiome analysis in chronic pancreatitis and pancreatic cancer patients revealed significant alterations in microbial composition, with reduced diversity and changes at both phylum and genus levels. These differences, including decreased beneficial and increased pathogenic species, could be indicative of disease. Further research is required…
An upward trend in total mortality rates was observed in a study analyzing traffic and nontraffic accident mortalities in northern Iran from 2016 to 2022. While traffic death rates showed a non-significant decrease, intentional nontraffic deaths displayed a significant upward trend. The findings highlight the…
A multi-center study in Japan found that proton-based definitive chemoradiotherapy (p-crt) showed equivalent 3-year overall survival (OS) compared to neoadjuvant chemotherapy followed by esophagectomy (nac-s) in esophageal squamous cell carcinoma patients. While the p-crt group had inferior progression-free survival (PFS), there was better survival in…
Following the implementation of a transdisciplinary perioperative care pathway, a significant decrease in major morbidity and intra-abdominal complications was observed, along with reduced need for unplanned interventions post emergency laparotomy. The pathway also led to increased assessments by geriatric medicine. These results indicate sustained improved…
A nomogram incorporating radiomics and dosiomics features, along with clinical factors, was developed to predict overall survival in esophageal squamous cell carcinoma (ESCC) patients undergoing definitive chemoradiotherapy. Dosiomics features outperformed radiomics features in predicting survival outcomes. The combined model exhibited significant differences in overall survival…
French intergroup guidelines provide recommendations for accurate diagnosis, treatment, and follow-up of ampullary tumors based on expert opinions and recent literature review. Emphasizing multidisciplinary approach, guidelines suggest endoscopic papillectomy or surgical papillectomy for adenoma, and pancreaticoduodenectomy for carcinoma. Adjuvant monochemotherapy or polychemotherapy is recommended for…
A novel single-layer continuous dunking pancreaticojejunostomy with falciform ligament reinforcement shows promising results in preventing post-operative pancreatic fistulae following pancreaticoduodenectomy. The technique demonstrated low complication rates and successful adjuvant chemotherapy completion in the majority of patients. This simplified approach offers a feasible and effective option…
Assessment by a multidisciplinary team conference, particularly with a liver surgeon present, was linked to better overall survival in patients with synchronous colorectal liver metastases. Patients residing near a hospital with a hepatobiliary unit were more likely to receive liver surgery and had improved median…
ERC-related procedures before biliary tract cancer surgery increase the risk of skeletal muscle mass loss. Post-ERC complications like pancreatitis and cholangitis are independent risk factors for large muscle mass decrease. Skeletal muscle mass decreases in most patients with BTC undergoing ERC, highlighting the importance of…
Dexmedetomidine significantly decreases postoperative acute kidney injury (AKI) incidence compared to controls (RR 0.60, 95% CI 0.45-0.78), shortening ICU and hospital stay but increasing bradycardia risk. Meta-analysis of 25 trials (n=3,997) demonstrates its efficacy in AKI prevention post-surgery, offering potential benefits in patient outcomes.
