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Best Papers in General Surgery
The five that matter, every day.
Postoperative complications in high-risk surgical populations increase mortality, disability, and costs. BIGPROMISE cohort profile discusses rationale and scope to investigate risk factors and outcomes related to postoperative complications. Over 3000 adult patients undergoing major surgery contribute data and biomarkers for analysis. With a focus on…
Patients in regions with poorer food environments exhibit higher odds of late-stage gastrointestinal cancer diagnosis and worse survival rates. These disparities are pronounced across various cancer types, highlighting the need for targeted interventions to mitigate socioeconomic and dietary influences on cancer outcomes.
Patients undergoing pancreaticoduodenectomy with a thick mesopancreas face significantly longer operative times, higher estimated blood loss, fewer resected lymph nodes, increased overall and major morbidities, and prolonged hospital stays. This study underscores the mesopancreas thickness as a critical predictor of surgical outcomes, surpassing the predictive…
Postoperative outcomes among patients treated by international medical graduate (IMG) surgeons were comparable to those by United States medical graduate (USMG) surgeons. IMG surgeons had lower rates of adverse postoperative outcomes, such as 90-day readmission and index complications. They were also more likely to care…
Postoperative complications were associated with significantly worse patient-reported outcomes, including lower physical and mental health scores, higher pain interference and fatigue, and lower physical function. A substantial number of patients reported outcomes below national benchmarks, emphasizing the need for improved post-surgical care to enhance patients'…
Among general surgery patients, major bleeding, sepsis, and myocardial injury after non-cardiac surgery (MINS) were independently associated with 30-day mortality. These complications had the largest attributable fraction of post-operative deaths. Findings suggest the need for strategies, such as perioperative bleeding prophylaxis, to reduce mortality in…
Success in rectal cancer treatment depends on predicting recurrence risks. Swedish registry data on 9428 patients revealed major impacts on distant recurrence from factors like pt4a, pn2b, tumor deposit, lymph node yield, and tumor level. Pathologic stage and identified risk factors guided different recurrence risks…
Early body-weight loss (< 37.7% EBWL) at 3 months post-laparoscopic sleeve gastrectomy predicts poorer long-term weight loss outcomes. High BMI, elevated neutrophil-to-lymphocyte ratio (≥ 2.36), and female sex are significant risk factors for suboptimal weight loss. These findings highlight the potential utility of targeted interventions…
Conversion from Sleeve Gastrectomy to Roux-en-Y Gastric Bypass significantly reduced GERD symptoms and PPI use, with 70% of patients experiencing complete symptom resolution and 60% discontinuing PPIs. This approach led to improved postoperative outcomes, decreasing daily symptoms of GERD and the need for PPIs. The…
Lombardy, Italy established pancreas units to improve outcomes for pancreatic cancer patients. The model, emphasizing centralized care, multidisciplinary collaboration, and minimum requirements, offers a structured framework for enhancing pancreatic cancer care. This initiative has the potential for broader application in regions and countries aiming to…
