Newsletter
Best Papers in General Surgery
The five that matter, every day.
Researchers found that negative pressure wound therapy (NPWT) can significantly reduce surgical site infections (SSIs) after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). A study of 178 patients showed lower SSI rates with NPWT (5.6%) compared to standard surgical dressing (11.4%). Multivariate analysis confirmed…
Researchers discuss current strategies and challenges in diagnosing and treating intraductal papillary neoplasms (IPNs) of the bile duct and pancreatic duct, which are precursors to pancreatic cancer and cholangiocarcinoma. Modern imaging, biomarkers, and molecular tests are aiding in diagnosis, but treatment should be individualized based…
Postoperative pancreatic fistula (POPF) is a common complication following pancreatectomy, with over sixty prediction models existing primarily for pancreaticoduodenectomy. However, these models have shown suboptimal accuracy across diverse populations. Future research should focus on developing and validating prediction models for distal and central pancreatectomy, incorporating…
A meta-analysis of five studies found that the pooled proportion of successful closure with over-the-scope clips (OTSC) for leaks and fistulae following bariatric surgery was 81.1% (95% CI 67.3 to 91.7). Observational reports suggest that patients managed with OTSC had higher rates of defect healing…
This study analyzed paraesophageal hernia repairs to identify factors influencing postoperative symptom improvement and radiographic recurrence. Propensity score matching compared initial and reoperative repairs, showing lower symptom improvement rates in reoperations but similar rates of recurrence and complications. Most patients experienced symptom improvement, despite frequent…
17% of general surgery residency graduates pursued academic surgery careers. Factors associated with this choice included graduating from a top-20 program, working with a research mentor, holding an advanced degree, and publishing during residency. Only research productivity during residency predicted early career success. Programs should…
Adjuvant chemotherapy following resection for adenocarcinoma from intraductal papillary mucinous neoplasia did not show reduced recurrence rates or improved survival outcomes in a multicenter study. Various chemotherapy regimens were not associated with superior outcomes in any high-risk subgroup, indicating that chemotherapy may not influence recurrence…
Researchers examined the concept of total neoadjuvant therapy (TNT) for pancreatic ductal adenocarcinoma (PDAC), finding that the term "total" is not consistently defined. Although it has gained popularity for its promise of comprehensive preoperative treatment, the current understanding and protocols vary widely, with inconsistent therapy…
Minimally invasive surgery for intrahepatic cholangiocarcinoma in patients at high risk of early recurrence provides better disease-free and overall survival compared to open surgery. Laparoscopic approach leads to shorter surgery-adjuvant treatment interval and higher rates of adjuvant therapy initiation within 2 months post-surgery. This study…
Researchers examined the outcomes of sleeve gastrectomy (SG) in patients with familial aggregation of obesity (FAO) compared to those with sporadic obesity (SO). The study, involving 193 patients, found no significant differences in baseline characteristics or short-term postoperative weight loss between FAO and SO groups.…
