Analysis of 125 patients with molecular profiling for intrahepatic cholangiocarcinoma revealed actionable molecular alterations in 45%, leading to targeted therapies in 21 patients. Patients with such alterations had significantly improved overall survival, with mean survival of 34.1 vs 23.6 months in those with actionable alterations. This highlights the importance of molecular profiling in guiding personalized […]
Category: General Surgery
Left-sided liver resection leads to lower mortality and better survival in perihilar cholangiocarcinoma
Left-sided liver resection for perihilar cholangiocarcinoma is associated with lower 90-day mortality and superior overall survival compared to right-sided resection. In a study of 1701 patients, 90-day mortality rates were 9% for left-sided and 18% for right-sided resection, with median overall survival of 30 months for left and 23 months for right. Left-sided resection was […]
High Accuracy Classification of Pancreatic Neoplasms Based on DNA Methylation Signatures.
DNA methylation profiling accurately classifies nonductal primary pancreatic neoplasms, with a random forest model achieving 96.9% accuracy and near perfect precision in identifying nonpancreatic neoplasms. Methylation signatures offer a valuable diagnostic tool with minimal misdiagnosis risk, even in preoperative settings. Journal Article by Verschuur AVD, Hackeng WM (…) Brosens LAA et 13 al. in Clin […]
Impact of Weekday Surgery on Colorectal Cancer Outcomes
Weekday surgeries for colorectal cancer patients showed no significant difference in mortality rates but were associated with slightly longer operative times and increased blood loss for colon cancer patients. Rectal cancer patients operated on Fridays had lower respiratory issues but higher rates of complications and longer hospital stays. The study’s findings suggest that the day […]
Developing a nuanced preoperative strategy for hernia repair
This viewpoint highlights the need for a nuanced preoperative optimization strategy in hernia repair, emphasizing patient and disease-specific factors to determine optimal surgical timing for personalized care. It discusses the variability in adherence to preoperative optimization and the lack of detailed data guiding surgical decision-making, calling for a more patient-centered approach to enhance outcomes and […]
Systemic Barriers for Black Trainees in Canadian Surgical Residency
The study explores the barriers faced by Black medical students and residents in completing surgical residency in Canada. Lack of mentorship, representation, experiences with racism, and systemic racism were identified as key obstacles. Gender intersectionality further exacerbated these challenges. There is a pressing need for diverse mentorship, acknowledgment of systemic racism, and creation of safe […]
Colorectal Surgeons Associated with Better Outcomes in Colorectal Surgeries
Surgeons found that outcomes of elective colectomies, proctectomies, and urgent colectomies were better when performed by colorectal surgeons (CRS) compared to general surgeons (GS). CRS had lower complication and mortality rates in all procedures analyzed. Hospitals lacking CRS may benefit from recruiting these specialists to improve patient outcomes. Journal Article by Purdy AC, Murphy S […]
Improved Pain Management and Recovery After Implementation of ERAS Protocol for CRS-HIPEC
Enhanced Recovery After Surgery (ERAS) protocol implementation for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) led to increased epidural use, decreased oral and intravenous opioid requirements, and earlier restoration of bowel function. Patients with epidurals had significantly lower opioid needs post-ERAS, with improved ambulation, diet initiation, and return of bowel function compared to pre-ERAS patients. […]
Spectral CT and Machine Learning Improve Preoperative Prediction of Gastric Cancer Invasion
Accurate preoperative prediction of lymphovascular and perineural invasion status in gastric cancer patients is crucial for identifying high-risk individuals. This study developed and tested a machine learning model that successfully combines spectral CT parameters and clinical indicators to accurately predict LVI/PNI status. The integration of portal venous and ep spectral CT parameters significantly enhances the […]
Safe Implementation of ERAS and Early Discharge Protocols for Robotic eTEP Hernia Surgery
Initial experience with enhanced recovery after surgery (ERAS) and early discharge protocols for robotic extended totally extraperitoneal (eTEP) hernia surgery demonstrates safety, feasibility, and acceptable short-term outcomes, with 69% of patients discharged on the same day as surgery. Journal Article by Liu YZ, Luhrs A (…) Giorgi M et 3 al. in Surg Endosc © […]