Implementing mobile health in surgical practice can improve patient outcomes, satisfaction, and system performance by addressing issues of poor communication and care coordination. Experts developed an implementation guide using human-centered design techniques, focusing on identifying mobile health use in surgical practice, mapping the pathway to implementation, and measuring impact on patients and the surgical system. […]
Category: General Surgery
High Rates of Pathologic Complete Responses with Neoadjuvant Immunotherapy for Mismatch Repair Deficient Colon Cancer
Neoadjuvant immunotherapy for non-metastatic, mismatch repair deficient colon cancer showed high rates of pathologic complete responses in locally advanced cases. Among 8 included studies, complete resections were achieved in 98-100% of cases, with 50-91% showing ypt0n0 pathology post-treatment. Safety profiles were generally favorable, with mostly immune-related grade 1-2 adverse events reported in 22.2-70% of patients. […]
Validation of a Quantitative Method for Precise Polyp Size and Location Measurement in Upper Gastrointestinal Endoscopy
Researchers validated a quantitative method for precise polyp size and location measurement in upper gastrointestinal endoscopy, critical for malignancy prediction and intervention planning. Using an electromagnetic tracking sensor, the method showed high accuracy in a simulated endoscopy setting, with an average polyp size of 12mm and reliable test-retest results. Comparisons with caliper measurements revealed non-significant […]
Functional liver remnant measured by preoperative gadoxetate disodium-enhanced MRI predicts post-hepatectomy liver failure
Gadoxetate disodium-enhanced MRI can predict post-hepatectomy liver failure. Low signal intensity of the remnant liver compared to the spleen post-contrast is associated with higher odds of liver failure. Functional liver remnant determined by this imaging can accurately predict post-hepatectomy liver failure, with a specific cut-off value and high sensitivity and specificity. This predictive tool may […]
Monitoring Hepatocellular Carcinoma Burden with Methylated ctDNA Quantification
Quantifying methylated circulating tumor DNA effectively monitors HCC burden without the need for biopsy. Tumor methylation scores rapidly decline postoperatively in surgical HCC patients. Preoperative tms moderately correlates with tumor burden on pathology. Δtms is better associated with tumor progression than Δalpha-fetoprotein, and a composite score improves tumor progression detection. These findings show that ctdna […]
Effective Infection of Pancreatic Tumors with Oncolytic Virus Expressing CD19 Antigen Triggers Enhanced Tumor Regression with CD19-CAR T Cells
Intravenous administration of an oncolytic virus (cf33) engineered to express a nonsignaling CD19 antigen (CD19t) effectively infected and expressed CD19t in pancreatic tumors, triggering cell killing and increased immunogenic response by CD19-CAR T cells. Combination therapy of virus+CAR T cells led to significant tumor regression in pancreatic cancer models. Journal Article by Chen C, Park […]
Early Cholecystectomy in SCD with Cholelithiasis Reduces Complications
Cholecystectomy for uncomplicated cholelithiasis in sickle cell disease (SCD) patients leads to lower postoperative vaso-occlusive crises compared to those with acute cholecystitis, chronic cholecystitis, or gallstone pancreatitis. Advanced clinical presentations are strong predictors of complications, with 73% of SCD patients showing advanced clinical presentation at the time of cholecystectomy. These findings suggest that early cholecystectomy […]
Continuous Preventable Mortality Review: Driving Reduction in Trauma Mortality
By using continuous preventable mortality review to guide provider education, the Arkansas Trauma System saw a progressive reduction in preventable or potentially preventable deaths from 2015 to 2022. A total of 1,979 trauma deaths were analyzed, with a 43% decrease in preventable or potentially preventable deaths. Education focusing on improving trauma care, particularly in reducing […]
Home Call Negatively Impacts Sleep and Surgeon Burnout
Home call for acute care surgeons results in decreased sleep and increased burnout, with even non-active home calls contributing to sleep loss and burnout. Each additional call or return to the hospital during home call further exacerbates these negative effects. This study highlights the importance of considering the frequency of calls and returns to the […]
Capsule-Based pH Testing Shows Limited Association with GERD Symptom Scores in Bariatric Surgery Patients
Researchers compared capsule-based pH testing and GERD symptom scoring in bariatric surgery patients. They found no significant difference in GERD symptom scores between patients with and without a diagnosis based on pH testing. Objective pH testing may aid in procedure selection and informed consent, potentially reducing risks for future GERD-related complications. Journal Article by Scott […]