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General Surgery

Best Papers in General Surgery

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Ann Med25 Feb 2024

Advances in Targeted Therapy for Cholangiocarcinoma Patients

Research highlights the poor 5-year survival rates post-surgical resection for cholangiocarcinoma patients and the effectiveness of gemcitabine combined with platinum as first-line chemotherapy for advanced cases. Targeted therapy shows promise, but challenges include adverse reactions, drug resistance, and individual differences. The study emphasizes the need…

Am J Gastroenterol24 Feb 2024

Improved Post-Polypectomy Colorectal Cancer Risk Prediction Using Comprehensive Model

Post-polypectomy colorectal cancer risk prediction was more accurate with a model including patient age, diabetes diagnosis, and baseline colonoscopy indication and polyp findings compared to a polyp-only model. The comprehensive model demonstrated superior performance in predicting colorectal cancer diagnosis in both the development and validation…

Gastrointest Endosc24 Feb 2024

EUS-Guided Gallbladder Drainage Outshines Cholecystostomy Tubes

EUS-guided gallbladder drainage using lumen-apposing metal stents (EUS-GBD-LAMS) is safer and associated with shorter hospital stays compared to percutaneous cholecystostomy tubes in nonsurgical candidates with acute cholecystitis. A systematic review and meta-analysis showed EUS-GBD-LAMS had lower rates of delayed and overall adverse events, making it…

J Gastroenterol Hepatol24 Feb 2024

Early-onset adenocarcinoma of esophagogastric junction shows significantly better postoperative survival compared to late-onset adenocarcinoma

Results from a population-based study comparing early-onset and late-onset adenocarcinoma of esophagogastric junction demonstrated significantly better overall and cancer-specific survival in early-onset cases. Kaplan-Meier curves, multivariate Cox regression analyses, propensity score matching, and competing risk models all consistently showed a more favorable prognosis in early-onset…

J Gastrointest Surg24 Feb 2024

Optimizing Long-Term Outcomes: Flap-Based Perineal Reconstruction Analysis

High-risk patients undergoing abdominoperineal resection and pelvic exenteration may benefit from immediate flap reconstruction using pedicled gracilis flaps. A total of 101 patients underwent unilateral gracilis flap reconstruction, with 7.9% developing early major complications and 12.9% developing late major complications. Minor complications occurred in 32.7%…