Newsletter
Best Papers in General Surgery
The five that matter, every day.
Skin wound healing often leads to abnormal scarring, such as keloids or hypertrophic scars, impacting millions globally. While the precise mechanisms remain elusive, evidence suggests ongoing inflammation in susceptible individuals perpetuates extracellular matrix changes, resulting in fibrotic lesions. Abnormal scarring, causing pain, functional impairment, and…
Examining 131 randomized placebo-controlled surgical trials, a systematic review revealed a scarcity of published pilot or feasibility studies to inform the design and execution of these challenging trials. Only four studies, focused on orthopedic and oral/maxillofacial surgery, conducted true pilot work. With a dearth of…
Analyzing tissue expander breast reconstruction cases (n=1986), researchers offered practical insights into regression modeling in surgical oncology. For breast-Q physical well-being, linear regression identified age, marital status, and dissection type as significant factors. Logistic regression for complications found BMI, age, bilateral reconstruction, and dissection type…
Analyzing 495,628 patients undergoing complex cancer surgery, researchers found that sex discordance between surgeons and patients (51.2%) was linked to a decreased likelihood of achieving optimal postoperative outcomes. Such discordance correlated with higher risks of complications and 90-day mortality. Intriguingly, male patients treated by female…
Examining 1404 Crohn's disease patients post-ileocecal resection, researchers identified high-risk factors for surgical recurrence (multiple surgeries, active smoking, penetrating or perianal disease). Biologic prophylaxis post-surgery lowered surgical recurrence in high-risk patients. Additionally, prophylaxis reduced endoscopic recurrence regardless of risk, suggesting its potential benefits across risk…
The 8th ECCO scientific workshop addressed postoperative recurrence (POR) in Crohn's disease after ileocolonic resection. Despite modern therapies, POR remains a challenge, impacting patients' lives. The workshop extensively reviewed data on preventive and treatment strategies, including medications, endoscopic procedures, and surgery. Synthesizing available knowledge, the…
In hepatectomy for hepatocellular carcinoma (HCC) using a 25-minute Intermittent Pringle's Maneuver (IPM), preoperative dexamethasone administration demonstrated benefits. The study included 270 patients, with the dexamethasone group exhibiting reduced hepatocellular injury, inflammatory response, and major complications, along with shorter hospital stays compared to the control…
Researchers developed a Mutation-Annotated Prognostic Score (MAPS) for intrahepatic cholangiocarcinoma (ICC) after resection, integrating TP53 and KRASG12 mutations with clinical parameters. The MAPS model, validated internally and externally, demonstrated superior predictive efficacy (c-indices 0.782 and 0.731, respectively) compared to existing models. It effectively identified ICC…
Examining 2,212 patients undergoing minimally invasive distal pancreatectomy (MIDP) for left-sided tumors, this study categorized participants into frail and nonfrail groups using the modified frailty index (MFI). The frail group (n=79) exhibited significantly higher clinically relevant postoperative pancreatic fistula, overall complications, and 90-day mortality (1.3%).…
Examining 122 patients across seven Chinese centers, researchers evaluated three laparoscopic approaches for anatomical liver resection of segment 8 (LALR-S8) in hepatocellular carcinoma. The laparoscopic ultrasonography-guided, hepatic vein-guided, and Glissonean approaches showed comparable short-term oncological outcomes. Complication rates were low (5.73%), with the hepatic vein-guided…
