Elra, or ex vivo liver resection and autotransplantation, offers a promising solution for patients with hepatic alveolar echinococcosis facing cavernous transformation of the portal vein. No intraoperative mortality in both treatment groups; 90-day mortality was 16.7%. Long-term survival for CTPV patients undergoing elra was 72.9%, compared to 29.6% for those treated conservatively. The data supports […]
Category: Transplant Surgery
New Classification System Improves Biliary Stricture Outcomes
Researchers developed a new classification for biliary strictures after liver transplantation, enhancing treatment choices and outcomes. Patients were classified into three types: type I (43.8%), type II (32.3%), and type III (24.0%). Type I patients using fully covered metal stents had fewer procedures and lower costs compared to plastic stents (p=0.02 and p=0.04). Stent-free success […]
Machine Learning Enhances Decision-Making in Hepatocellular Carcinoma Treatment
A machine learning model accurately predicts optimal treatment choices for hepatocellular carcinoma, comparing liver transplantation to surgical resection. The model stratifies patients into high- and low-risk groups, estimating potential survival improvements from tailored decisions. In a nationwide study of over 4,500 patients, machine learning outperformed traditional clinical decision-making approaches, suggesting enhanced outcomes. These findings underscore […]
Conversion therapy extends survival for locally advanced intrahepatic cholangiocarcinoma patients
Conversion therapy (CT) significantly improves overall and progression-free survival in patients with locally advanced intrahepatic cholangiocarcinoma (LA-ICCA). In a retrospective analysis of 115 patients, median overall survival reached 45.53 months and progression-free survival was 18.23 months post-propensity score matching, both superior to systemic therapy (ST) outcomes. CT emerged as an independent factor linked to better […]
New deep learning models excel in organ donation image segmentation
Deep learning models, detectron2 and yolov8, significantly improved automated segmentation in organ donation photography, achieving internal validation Intersection over Union (IoU) scores of 0.93 and 0.94 for kidneys, and 0.97 for livers. Compared to traditional methods, which peaked at IoU 0.54, these new models demonstrated superiority in accuracy and speed, completing tasks in just 0.13-1.5 […]
Comprehensive Classification of Right Intrahepatic Portal Vein Branching
A study analyzing the branching patterns of the right intrahepatic portal vein identified 12 distinct types, emphasizing the anatomical variations of the right anterior and posterior portal veins. Three-dimensional visualization technology was utilized to analyze 711 patients, revealing the cranio-caudal and ventro-dorsal configurations among others. These findings provide clinicians with critical insights into portal vein […]
Liver transplant with sleeve gastrectomy sustains weight loss and reduces obesity-related complications
The study demonstrates that simultaneous liver transplant and sleeve gastrectomy leads to significant long-term weight loss, improved diabetes and hypertension outcomes, and lower rates of allograft steatosis compared to liver transplant alone. Over a follow-up period, ltsg patients, starting with a higher average BMI, showed remarkable post-operative results, including a decrease in diabetes prevalence and […]
Unique barriers identified for marginalized HCC patients
Marginalized groups, particularly black patients and those affected by adverse social determinants of health, encounter significant barriers to curative treatments for hepatocellular carcinoma (HCC). Research revealed common challenges, such as information overload and communication gaps, while black patients also faced psychological burdens and systemic distrust. Conversely, patients experiencing adverse social determinants reported financial instability and […]
Immunotherapy transforms surgical management of advanced liver cancer.
Immune checkpoint inhibitors are reshaping treatment for advanced hepatocellular carcinoma, establishing new standards and encouraging further research. A combination of atezolizumab and bevacizumab shows high response rates, prompting investigations into their roles in peri-operative settings and liver transplantation. However, there are concerns regarding immunosuppression and graft rejection, necessitating careful patient selection and management. Ongoing studies […]
Adipose-derived stem cells enhance pancreatic islet revascularization.
Co-transplantation of adipose tissue-derived mesenchymal stem cells (ADMSCs) with pancreatic islets into decellularized pancreatic skeletons improved vascularization and preserved islet morphology. While ADMSCs did not suppress immune responses in vivo, their presence reduced the proliferation of splenocytes in vitro. In contrast, endothelial cell co-transplantation resulted in islet-cell necrosis. These findings indicate that ADMSCs are effective […]