A predictive nomogram was developed to assess the risk of postoperative complications in gastric cancer patients undergoing robotic-assisted radical gastrectomy. The study analyzed data from 636 patients across two cohorts and identified five independent risk factors: tumor diameter, TNM stage III, ASA classes I and III, and visceral fat area. The nomogram demonstrated good discrimination, […]
Category: Upper Gastrointestinal Tract
Eight interventions proved effective in preventing post-operative stenosis
A systematic review and network meta-analysis identified eight effective interventions for preventing postoperative esophageal stenosis following endoscopic resection of superficial cancer. Notable approaches included the combination of polyglycolic acid with a steroid and botulinum toxin. These interventions also led to significant reductions in the number of endoscopic balloon dilatation sessions needed. Importantly, none of the […]
Tumor-Stroma Ratio Accurately Predicts Peritoneal Metastasis in Gastric Cancer
Analysis reveals a strong correlation between tumor-stroma ratio (tsr) and peritoneal metastasis (pm) in gastric cancer patients. The study included 640 patients across several cohorts, establishing a diagnostic model integrating tsr with CA125, CA724, and Borrmann type. The model demonstrated robust predictive capabilities, achieving an area under the curve (AUC) of 0.85 in the training […]
Preoperative ctDNA status predicts recurrence risk in esophageal cancer
Preoperative circulating tumor DNA (ctDNA) analysis shows significant prognostic value in patients with esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemotherapy followed by surgery. Among 25 patients, those with ctDNA detected post-treatment faced a recurrence-free survival rate of only 8% at 36 months, compared to 92% for ctDNA-negative patients (p < 0.001). These findings highlight […]
Significant research waste identified in gastroesophageal trials
Over the past 20 years, an analysis of 182 randomized controlled trials (RCTs) on gastroesophageal reflux disease and hiatal hernia highlighted that over 86.7% exhibited significant research waste. The majority of trials were drug-related, primarily conducted in North America and Asia, with deficiencies found in various aspects such as reporting adequacy and design flaws. This […]
Nomogram effectively predicts postoperative pneumonia post-esophageal ESD
A novel nomogram has been developed to predict postoperative pneumonia risk after esophageal endoscopic submucosal dissection (ESD). In a cohort of 492 patients, the incidence of pneumonia was 18.6%. Key predictive factors included female sex, older age, low serum albumin levels, prolonged operative duration, muscular layer damage, and comorbid pulmonary diseases. The nomogram exhibited robust […]
Tumor downstaging improves survival in esophageal adenocarcinoma patients
Analysis of 6,400 esophageal adenocarcinoma patients revealed that 51% experienced tumor downstaging after neoadjuvant chemoradiation, with complete downstaging noted in 5%. Downstaging correlated with a 31% and 17% reduced risk of death compared to disease progression and stable staging, respectively. Additionally, robotic-assisted minimally invasive esophagectomy reduced mortality risk by 17% compared to open surgery, while […]
Risk model predicts surgical adverse events in esophagectomy patients
A risk stratification model for surgical adverse events (SAEs) in minimally invasive esophagectomy (MIE) was developed and validated using data from 747 patients. The model identified key risk factors, including chronic obstructive pulmonary disease and low albumin levels, achieving areas under the curve of 0.889 and 0.793 for the training and validation sets, respectively. Patients […]
DCNN Model Enhances Early Gastric Cancer Diagnosis
A study established a deep convolutional neural network (DCNN) system that significantly improved diagnostic accuracy for early gastric cancer (EGC). In independent tests, the model achieved an area under the curve (AUC) of 0.917 and sensitivity of 93.38% for image datasets, while video tests showed an AUC of 0.930 and 96.92% sensitivity. Novice endoscopists reached […]
Surgical Trends and Outcomes in Korean Gastric Cancer Patients
The 2023 nationwide survey by the Korean Gastric Cancer Association revealed that early gastric cancer comprised 63.1% of cases. Notably, the mean patient age increased to 64.6 years, with those aged ≥71 rising to 31.7% since 1995. The use of totally laparoscopic surgery was predominant at 63.2%, with robotic techniques growing to 9.5%. Post-operative mortality […]