The study establishes that cumulative post-esophagectomy C-reactive protein (CRP) levels significantly predict cancer recurrence and survival outcomes in patients. Among 125 subjects, those with lower CRP levels on day 7 demonstrated notably improved recurrence-free and overall survival rates compared to those with elevated levels. The research identified specific CRP cut-off values, highlighting the importance of […]
Category: Upper Gastrointestinal Tract
Circulating biomarkers predict peritoneal metastasis in gastric cancer
A prospective clinical study evaluates the predictive effects of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in peritoneal lavage fluid for metachronous peritoneal metastasis (PM) in gastric cancer patients following radical resection. A total of 200 patients will be monitored over two years, with a primary focus on PM incidence one year post-surgery. […]
Nearly half of T2N0 gastric cancer patients experience upstaging
Among 4,076 patients with clinical T2N0 gastric adenocarcinoma undergoing upfront resection, 47.4% were pathologically upstaged. Factors increasing upstaging included tumor size over 3.0 cm and poor differentiation. In patients upstaged, adjuvant chemotherapy correlated with significantly improved survival, whereas it had no survival benefit in non-upstaged patients. These findings suggest that surgical intervention may be prioritized […]
Laparoscopic repair reduces mortality for peptic ulcer perforation
In a systematic review of nine randomized controlled trials involving 670 patients, laparoscopic repair for peptic ulcer perforation (PUP) demonstrated significantly lower mortality rates (risk ratio 0.37) and morbidity, alongside a reduced length of hospital stay compared to open surgery. The findings suggest that laparoscopic repair is preferable for PUP treatment, contingent upon available surgical […]
Surgical intervention improves survival in liver-only gastric metastases
Analysis of 10,977 patients with gastric adenocarcinoma and liver-only metastases revealed that those undergoing primary tumor resection combined with liver metastasectomy experienced significantly longer median overall survival (18.6 months) compared to non-surgical treatment (6.5 months). The study indicates that surgical resection, especially in highly selected patients with favorable biology, is associated with improved survival outcomes. […]
Increased NSAID use correlates with higher marginal ulcer risk.
A retrospective study of 6,888 patients with gastrojejunostomy revealed a dose-dependent relationship between nonsteroidal anti-inflammatory drug (NSAID) prescriptions and the development of marginal ulcers. Among those studied, 45.2% were exposed to NSAIDs, with 10.12% developing ulcers. The odds of ulcer increased significantly with the number of NSAID exposures, from 1.67 for 1-2 prescriptions to 2.42 […]
Laparoscopic approach reduces infectious complications in older patients
In a study comparing laparoscopic distal gastrectomy (LDG) and open distal gastrectomy (ODG) in older adults with locally advanced gastric cancer, LDG showed significantly lower rates of postoperative infectious complications. Among matched patients, only 3.4% of those undergoing LDG experienced complications compared to 27.6% for ODG. Though LDG had a longer operative time, it also […]
Anti-reflux surgery effectively alleviates gastroesophageal-related cough symptoms.
A systematic review and meta-analysis of 59 studies involving 7,431 patients with gastroesophageal reflux disease (GERD) revealed that anti-reflux surgery significantly improves gastroesophageal-related cough, with an 80% remission rate. Additionally, heartburn and regurgitation remission rates were 87.7% and 91.2%, respectively. These findings underscore the efficacy of surgical interventions for managing common reflux symptoms, suggesting that […]
TIF 2.0 demonstrates high success rates for GERD treatment
A prospective multicenter study tracked outcomes in patients with GERD after transoral incisionless fundoplication (TIF 2.0). Clinical success was achieved in 94% of participants, with improvements in GERD-specific health scores for 89% and a normalization of elevated reflux symptom index (RSI) in 85%. Patient satisfaction surged from 8% to 79%, and 80% of patients required […]
Higher positive lymph node ratio predicts worse survival in esophageal cancer
Findings indicate that the positive lymph node ratio (plnr) significantly predicts overall and disease-free survival in locally advanced esophageal squamous cell carcinoma (ESCC). Out of 439 patients, higher plnr was associated with poorer survival outcomes, with an optimal cutoff identified at 10%. Major prognostic factors include plnr and metastatic lymph nodes along the left gastric […]