A randomized clinical trial involving 264 patients with early distal gastric cancer demonstrated that preserving the vagus nerve during laparoscopic distal gastrectomy significantly reduced the incidence of postoperative gastroparesis (0.8% vs. 7.6%) and gallstone formation (0% vs. 6.8%) compared to resection. Quality of life assessments revealed the vagus nerve preservation group experienced fewer nausea, vomiting, […]
Category: Upper Gastrointestinal Tract
Predictive model developed for cachexia in gastric cancer patients
A new prognostic model for cachexia in postoperative gastric cancer patients was developed and validated across two cohorts. Focusing on twelve key factors, the model achieved promising performance with AUC values of 0.805 in the training set and 0.795 in the external validation cohort. Calibration and decision curve analyses confirmed its clinical utility, enabling healthcare […]
H. pylori infection identified as key factor in gastric cancer recurrence
A machine learning study involving 1,234 gastric cancer patients revealed that H. pylori infection is the predominant high-risk factor for cancer recurrence post-gastrectomy. Utilizing four algorithms, the XGBoost model outperformed others in accuracy, identifying critical risk elements such as tumor invasion depth and lymph node metastasis. The findings suggest that machine learning can aid clinicians […]
Risk scoring model effectively predicts peritoneal recurrence in gastric cancer
The study identified key risk factors for peritoneal recurrence (PR) in gastric cancer, involving 622 patients post-gastrectomy. Among these, 64 experienced PR with significantly poorer survival rates compared to those with recurrence in other sites. A newly developed risk-scoring model, based on eight variables, demonstrated 81% accuracy in predicting PR. Notably, 82.8% of patients with […]
Small-sized capsule gastroscopy effectively screens gastrointestinal diseases
A retrospective analysis involving 2,163 asymptomatic individuals revealed that small-sized magnetically controlled capsule gastroscopy (mccg) successfully detected gastrointestinal issues such as submucosal tumors (1.57%), polyps (15.16%), and ulcers (1.25%). Detection rates for polyps were notably higher in females and increased with age. The procedure was well-tolerated, with no significant discomfort or adverse events reported, demonstrating […]
Endoscopic submucosal dissection is pivotal for early gastric cancer treatment
Endoscopic submucosal dissection (ESD) is crucial for early gastric cancer (EGC) management, often necessitating additional gastrectomy in cases deemed non-curative. Analysis of 134 patients revealed key factors such as deep submucosal invasion and positive margins that led to further surgical intervention. Notably, independent risk factors for lymph node metastasis included positive vertical margin and lymphatic […]
Bolus exposure predicts postoperative symptom resolution better.
In a retrospective study involving 72 patients, bolus exposure emerged as a superior predictor for postoperative symptom resolution in gastroesophageal reflux disease (GERD) after laparoscopic Nissen fundoplication. It outperformed traditional parameters like acid exposure time and DeMeester score for predicting symptom relief, notably for epigastric pain and regurgitation. Notably, in patients without pathological reflux, bolus […]
Adjuvant chemotherapy improves survival in select gastric cancer patients
Findings reveal that adjuvant chemotherapy significantly enhances overall survival in patients with locally advanced gastric cancer post-neoadjuvant chemotherapy. Specifically, those receiving adjuvant therapy showed a 2-year overall survival rate of 86.2% compared to 64.1% for those who did not (p = 0.002). Critical factors influencing adjuvant treatment inclusion included patient age and ASA grade, while […]
Machine learning model predicts malignant potential of gastric tumors
A novel machine-learning model effectively predicts the malignant potential of gastric gastrointestinal stromal tumors (GISTs), identifying key risk factors such as endoscopic ultrasound features, tumor margin clarity, diameter, and monocyte-to-lymphocyte ratio. Tested with 318 patients, the logistic classification model achieved high performance with area under the curve values of 0.919 and 0.925 for training and […]
Standardized management strategies established for failed fundoplications
An international expert panel formulated 33 statements addressing the definition and management of post-fundoplication symptoms. With over 80% agreement, the consensus focuses on resolving symptoms rather than achieving normal physiology. Key areas addressed include dysphagia, heartburn, and the appropriateness of revisional surgeries, along with necessary investigations for symptomatic patients. This initiative marks the first global […]