Evidence suggests that surgical intervention, prior to peptide receptor radionuclide therapy, significantly enhances progression-free survival for patients with metastatic gastroenteropancreatic neuroendocrine tumors. In a study of 89 well-matched patients, those who underwent surgery had a median progression-free survival of 26.1 months, compared to 15.6 months in the no-surgery group (p = .04). Furthermore, liver debulking […]
Category: Upper Gastrointestinal Tract
Lymph node ratio predicts survival in duodenal adenocarcinoma
The lymph node ratio (LNR) has been identified as a crucial prognostic factor in patients with postoperative duodenal adenocarcinoma. In a study involving 943 patients, those with an LNR of 0.12 or greater experienced poorer overall survival. A nomogram integrating key prognostic factors, including LNR and tumor size, provided effective risk stratification. High-risk patients benefited […]
Vascular navigation system reduces complications in laparoscopic gastrectomy
A patient-specific vascular navigation system demonstrated clinical feasibility in laparoscopic gastrectomy for gastric cancer, with no adverse events reported during surgeries. Compared to 114 patients without the system, those using it had significantly lower overall complication rates (10.5% vs. 26.3%, p=0.043) and no pancreas-related complications encountered. The findings suggest that integrating this navigation tool can […]
Hyperthermic Intraperitoneal Chemotherapy Enhances Survival in Gastric Cancer
A meta-analysis of 12 randomized controlled trials involving 1,181 gastric cancer patients demonstrated that hyperthermic intraperitoneal chemotherapy (HIPEC) significantly improved survival rates compared to control groups at 1, 2, 3, and 5 years. The recurrence rates were notably lower in the HIPEC group, and higher disease-free survival rates were also observed. These findings suggest that […]
Predictive model established for early esophageal cancer invasion
A logistic regression model developed from various risk factors effectively predicts early esophageal cancer with submucosal infiltration beyond 200 micrometers. Key predictive factors include endoscopic findings, esophageal wall thickening, pickled food intake, platelet-lymphocyte ratio, tumor size, circumferential mucosal defect percentage, and preoperative pathological type. The model demonstrated high efficacy, achieving an area under the curve […]
Postoperative C-reactive protein levels forecast esophageal cancer outcomes
The study establishes that cumulative post-esophagectomy C-reactive protein (CRP) levels significantly predict cancer recurrence and survival outcomes in patients. Among 125 subjects, those with lower CRP levels on day 7 demonstrated notably improved recurrence-free and overall survival rates compared to those with elevated levels. The research identified specific CRP cut-off values, highlighting the importance of […]
Circulating biomarkers predict peritoneal metastasis in gastric cancer
A prospective clinical study evaluates the predictive effects of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in peritoneal lavage fluid for metachronous peritoneal metastasis (PM) in gastric cancer patients following radical resection. A total of 200 patients will be monitored over two years, with a primary focus on PM incidence one year post-surgery. […]
Nearly half of T2N0 gastric cancer patients experience upstaging
Among 4,076 patients with clinical T2N0 gastric adenocarcinoma undergoing upfront resection, 47.4% were pathologically upstaged. Factors increasing upstaging included tumor size over 3.0 cm and poor differentiation. In patients upstaged, adjuvant chemotherapy correlated with significantly improved survival, whereas it had no survival benefit in non-upstaged patients. These findings suggest that surgical intervention may be prioritized […]
Laparoscopic repair reduces mortality for peptic ulcer perforation
In a systematic review of nine randomized controlled trials involving 670 patients, laparoscopic repair for peptic ulcer perforation (PUP) demonstrated significantly lower mortality rates (risk ratio 0.37) and morbidity, alongside a reduced length of hospital stay compared to open surgery. The findings suggest that laparoscopic repair is preferable for PUP treatment, contingent upon available surgical […]
Surgical intervention improves survival in liver-only gastric metastases
Analysis of 10,977 patients with gastric adenocarcinoma and liver-only metastases revealed that those undergoing primary tumor resection combined with liver metastasectomy experienced significantly longer median overall survival (18.6 months) compared to non-surgical treatment (6.5 months). The study indicates that surgical resection, especially in highly selected patients with favorable biology, is associated with improved survival outcomes. […]