Researchers found that endoscopic submucosal dissection (ESD) offers superior clinical outcomes for early oesophageal cancer compared to endoscopic mucosal resection (EMR). ESD demonstrated a shorter hospitalization time (7.51 vs. 9.16 days) and a significantly better postoperative quality of life. Although ESD surgeries took longer, both techniques achieved comparable resection rates. Importantly, ESD resulted in fewer […]
Category: Upper Gastrointestinal Tract
High-Volume Centers Offer Better Long-Term Survival for Esophageal Cancer Surgery
Patients undergoing esophagectomy for cancer at high-volume centers exhibit improved long-term survival, as shown in a meta-analysis involving 23,194 individuals. Those treated in these centers lived an average of 4.3 months longer compared to their counterparts in low-volume centers. The analysis also indicated a significantly reduced risk of mortality over a 60-month follow-up period. This […]
Predictive model enhances surgical planning for advanced gastric cancer
A new predictive model developed for assessing surgical difficulty in distal gastrectomy for advanced gastric carcinoma shows promise. An analysis of 520 patients revealed seven independent risk factors, including BMI and tumor size. The model achieved an impressive area under the curve (AUC) of 0.787, indicating strong predictive accuracy. This tool aims to aid surgeons […]
New nomogram predicts survival for signet ring cell gastric cancer patients
A novel prognostic nomogram has been developed for predicting overall survival (OS) and cancer-specific survival (CSS) in signet ring cell gastric cancer patients post-surgery. Analyzing data from 3,481 patients, researchers identified critical independent prognostic factors, including race, chemotherapy, and lymph node ratio. The nomogram demonstrated impressive accuracy with a c-index of 0.748 for OS and […]
Pathological complete response enhances survival in esophageal cancer.
A recent meta-analysis indicates that pathological complete response (pCR) following neoadjuvant chemoradiotherapy significantly improves long-term survival outcomes in patients with locally advanced esophageal cancer undergoing surgery. Findings from 38 included studies revealed a hazard ratio of 0.54 for overall survival and 0.51 for disease-free survival among those achieving pCR. Subgroup analyses showed even greater benefits […]
Nomogram effectively predicts anastomotic leakage in elderly patients.
A LASSO-based nomogram has been developed to predict anastomotic leakage (AL) in elderly patients undergoing laparoscopic gastrectomy. An analysis of 884 patients identified significant predictors, including age, ASA score, diabetes, intraoperative blood loss, and prognostic nutritional index. The nomogram demonstrated high predictive accuracy, achieving AUC values of 0.870 and 0.890 in training and validation cohorts, […]
Cryopreserved fibroblast sheets reduce esophageal leakage risk
Cryopreserved allogeneic multilayered fibroblast sheets demonstrated efficacy in preventing esophageal anastomotic leakage in a rat model. The incidence of leakage was significantly lower in the fibroblast sheets group (28%) compared to controls (61%; p = .02). Additionally, the burst pressure was notably higher in the sheet group (124 ± 30 mm Hg) versus controls (78 […]
Effective Management Strategies for Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) poses challenges with its typical and atypical presentations requiring careful diagnosis. Key diagnostic tools like endoscopy, manometry, and reflux monitoring are essential for confirming GERD and tailoring treatment. Management varies from lifestyle modifications to pharmacologic therapies, with surgical options available for persistent cases. Effective treatment can significantly improve prognosis and quality […]
Linear stapled techniques reduce anastomotic leakage post-esophagectomy.
A study of 1,518 patients undergoing robot-assisted minimally invasive esophagectomy identified significant differences in anastomotic leakage rates among various surgical techniques. The linear stapled side-to-side anastomosis had the lowest leakage rate at 14.0%, while the handsewn end-to-end method had the highest at 32.8%. Both univariable and multivariable analyses confirmed that handsewn techniques carried a higher […]
Advances in treating peritoneal oligometastasis in gastric cancer
Peritoneal metastasis from gastric cancer significantly impacts prognosis, but advancements in diagnostic and therapeutic strategies are transforming patient outcomes. A peritoneal cancer index (PCI) threshold of ≤6 identifies patients with oligometastasis who may benefit from aggressive therapies. Cytoreductive surgery coupled with hyperthermic intraperitoneal chemotherapy remains essential for curative intent. Emerging techniques like normothermic and pressurized […]