Fluorodeoxyglucose positron emission tomography (FDG-PET) effectively predicts lymph node status and prognosis in patients with esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy after neoadjuvant chemotherapy (NCT). Researchers reviewed data from 124 ESCC patients and found that FDG-PET pre- and post-NCT correlated significantly with pathological lymph node metastasis, with post-NCT assessments serving as an independent predictor […]
Category: Upper Gastrointestinal Tract
Effectiveness of Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer
A meta-analysis of 16 randomized controlled trials with 1,641 patients assessed the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) for treating and preventing peritoneal carcinomatosis in advanced gastric cancer. Surgery plus HIPEC improved overall survival in both prophylactic (HR 0.56) and therapeutic (HR 0.57) settings, with a 3-year mortality rate of 32% for the prophylactic HIPEC […]
Computed Tomography Radiogenomics: Predicting Molecular Subtypes in Gastric Stromal Tumors
A combined model integrating clinical and contrast-enhanced computed tomography (CE-CT) features accurately predicts specific genetic mutations in gastrointestinal stromal tumors (GISTs). Researchers developed three models from data from 231 GIST patients, with the best model achieving high accuracy in predicting molecular subtypes. In the training cohort, the area under the curve (AUC) values indicated significant […]
Development and Validation of Risk Score Model for Assessing Lymph Node Metastasis in Early Gastric Cancer
Endoscopic ultrasonography (EUS) offers 85.3% accuracy in detecting lymph node metastasis in early gastric cancer. A risk score model based on preoperative factors, such as tumor size, lymph nodes, and BMI, provides guidance for treatment selection, despite low sensitivity and PPV. This tool aids clinicians in predicting lymph node involvement and choosing optimal management strategies […]
Self-inflatable Balloon for Treating Refractory Benign Esophageal Strictures
The novel self-help inflatable balloon (SHIB) showed high efficacy and safety in treating refractory benign esophageal strictures, with a clinical success rate of 51.2%. Patients experienced significant improvements in dysphagia scores, decreased stricture length, and prolonged intervention-free intervals. Endoscopic resection was particularly effective, with stricture etiology and wearing time identified as predictors of recurrent stricture. […]
Contemporary Outcomes of Left Thoraco-Abdominal Esophagectomy for Esophageal Cancer
A multicenter cohort study on left thoraco-abdominal esophagectomy for esophageal or gastroesophageal junction cancer showed favorable outcomes. Key results include low mortality rates, common postoperative complications, and survival associations with tumor characteristics and treatment modalities. The study highlights the feasibility and efficacy of this open surgical technique in selected patients, offering comparable results to other […]
Gender Disparities in Gas and Bloat Symptoms Post-Anti-Reflux Procedures
Female patients are more likely to experience higher gas/bloat scores after anti-reflux procedures compared to males. Despite similar rates of hernia recurrence, females also exhibit higher GERD-specific quality of life scores post-procedure. Results suggest the need for tailored treatments and prognostication for GERD patients based on sex differences. Journal Article by Zimmermann CJ, Kuchta K […]
Impact of Surgeon Age on Long-Term Survival After Gastrectomy
In this population-based cohort study involving 1,647 patients undergoing gastrectomy for gastric adenocarcinoma, surgeon age ≥47 years was associated with worse 5-year all-cause mortality rates. Adjusted hazard ratios for surgeons aged 55+ were 1.21 (95% CI 1.04 to 1.41), and for those aged 47-54 were 1.16 (95% CI 0.99 to 1.36), compared with those aged […]
Advancements in Endoscopic Cryotherapy in Gastrointestinal Diseases
Endoscopic cryotherapy has shown safety and efficacy in treating gastrointestinal conditions, including complete eradication of dysplasia and neoplasia in Barrett’s esophagus. It serves as a second-line treatment for refractory cases and an alternative to surgical resection for duodenal adenomas. Innovative applications for gastrointestinal bleeding and esophageal strictures have also been reported. Overall, endoscopic cryotherapy is […]
Safety and efficacy of a PD-1 inhibitor combined with oxaliplatin plus S-1 in patients with Borrmann large type III and IV gastric cancers
Clinicians evaluated the safety and efficacy of combining a programmed cell death 1 (PD-1) inhibitor with oxaliplatin plus S-1 (SOX) for treating Borrmann large type III and IV gastric cancers. In this retrospective analysis involving 89 patients, those who received PD-1 combined with SOX (P-SOX) had a significantly higher pathological response rate (42.86% with tumor […]