Category: Upper Gastrointestinal Tract

One-fifth of refractory caustic esophageal stricture patients benefit from endoscopic treatment.

Only 20% of patients with caustic refractory benign esophageal strictures (CRBES) were successfully treated with stepwise endoscopic interventions. The success rate was notably higher in those with the recurrent subtype (73%) versus the refractory subtype (0%). A significant 80% of patients eventually required esophageal reconstruction, which demonstrated a high success rate, achieving nutritional autonomy in […]

Inflammation increases the risk of gastroesophageal reflux disease

A bidirectional Mendelian randomization analysis has established causal links between inflammatory cytokines and gastroesophageal reflux disease (GERD). Specifically, higher levels of C-X-C motif chemokine 1, interleukin-1-alpha, and interleukin-4 were found to increase GERD risk, while tumor necrosis factor ligand superfamily member 12 appeared to reduce it. Additionally, while several metabolites associated with elevated IL-4 levels […]

Different surgical options show varying effectiveness for GERD relief

A meta-analysis involving 9,516 patients found that all surgical procedures for gastroesophageal reflux disease (GERD) significantly improved post-operative outcomes. Nissen fundoplication outperformed transoral incisionless fundoplication in reducing acid exposure and Demeester scores. However, Toupet fundoplication and magnetic sphincter augmentation provided superior symptom relief compared to other methods. These insights enhance understanding of various surgical anti-reflux […]

Stemness subtype of gastric cancer linked to higher metastasis risk

Research highlights two molecular subtypes of gastric cancer, revealing that the stemness subtype substantially increases the risk of hematogenous metastasis (HM). Through analyses of bulk-rna sequencing from 64 samples and a patient-derived xenograft model, the study identified 10 stemness signature genes. These genes helped stratify patients into HM risk groups, demonstrating a notable decrease in […]

ω-3 fish oil emulsion significantly reduces gastric emptying delays

A retrospective cohort study involving 210 patients revealed that perioperative ω-3 fish oil fat emulsion notably lowers the incidence of delayed gastric emptying (DGE) following Roux-en-Y reconstruction for gastric cancer, with rates dropping from 15.5% to 4.3% in the intervention group. Additionally, the ω-3 group benefited from a reduced median hospital stay of 10 days […]

Predictive model for liver metastasis risk in AEG patients

A novel nomogram accurately predicts the risk of postoperative liver metastasis in patients with adenocarcinoma of the esophagogastric junction (AEG) based on six independent factors: type of surgery, N stage, tumor differentiation, vascular thrombus, intestinal type, and p53 status. High predictive accuracy was demonstrated with a concordance index exceeding 0.96 in both training and validation […]

High Postoperative IL-6 Levels Deteriorate Outcomes in Esophageal Cancer

Elevated serum interleukin-6 (IL-6) levels one day post-minimally invasive esophagectomy (MIE) correlate with significantly poorer overall survival rates and nutritional status in esophageal cancer patients. In a cohort of 336 patients, those with IL-6 levels ≥60 pg/ml exhibited a 2-year overall survival rate of 69.8%, compared to 80.6% for those with lower levels. The study […]

Combination of omega-3 PUDAs and alanyl-glutamine enhances recovery

Alanyl-glutamine and omega-3 polyunsaturated fatty acids positively influenced postoperative outcomes in patients with gastroduodenal perforations. In a study involving 168 patients, those receiving the combination therapy experienced significant increases in total protein and albumin levels, alongside reduced C-reactive protein levels, indicating lower inflammation. Notably, group C (receiving both treatments) had the shortest hospitalization time and […]

Chewing gum significantly reduces postoperative ileus duration

A multicentre randomized controlled trial involving 52 patients revealed that chewing gum can significantly shorten postoperative ileus following laparotomy for gastroduodenal perforations. The median duration of ileus was reduced by 21.5 hours in patients who chewed gum compared to those who did not (28.5 hours vs. 50 hours, p=0.002). Additionally, the length of hospital stay […]