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Trisectionectomies Boost Survival in Perihilar Cholangiocarcinoma

Trisectionectomies (TS) dramatically enhance overall and disease-free survival for patients with Bismuth-Corlette type II and III perihilar cholangiocarcinoma, outperforming standard hemihepatectomies (EH). In a study of 443 patients, TS improved overall survival to 52.4 months compared to 31 months for EH. Although TS resulted in higher rates of liver failure, morbidity and mortality rates remained similar between the two surgical approaches. Consider TS as a vital option when feasible.

Journal Article by Tzedakis S, Dhote A (…) Boudjema K et 23 al. in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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New Model Predicts Recurrence Risk in Pancreatic Tumors

A predictive model effectively identifies patients with non-functioning pancreatic neuroendocrine tumors (NF-PanNETs) at high risk for early recurrence (ER). Developed from a cohort of 496 patients, the model leverages preoperative clinical, pathological, and imaging variables, achieving an AUC of 0.91 in training and 0.84 in validation. Neoplastic venous thrombosis emerged as the strongest recurrence predictor, with a 71% ER probability, while specific tumor characteristics provided additional risk stratification.

Journal Article by Partelli S, Guarneri G (…) Falconi M et 7 al. in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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New Insights Transforming Advanced Liver Cancer Treatment

With primary liver cancer often diagnosed too late for surgery, systemic treatments are becoming vital. The review highlights advances in molecular targeted therapies and immunotherapies, including cutting-edge combinations that suppress disease progression, extend survival, and enhance quality of life for patients. Challenges in implementation remain, but the evolving landscape of systemic therapies promises new avenues for better outcomes in advanced liver cancer management.

Review by Li CB, Ning YT (…) Luo G et 3 al. in World J Hepatol

©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

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Male Sex and Acute Cholecystitis Raise Bile Duct Injury Risk

Male sex and acute cholecystitis significantly elevate the risk of bile duct injury during cholecystectomy, with adjusted odds ratios of 1.27 and 1.74, respectively. The meta-analysis, examining over 6.5 million surgeries, also found inconsistent documentation of the critical view of safety, which lacked a statistical link to reduced injury rates. Routine use of intraoperative cholangiograms did not correlate with decreased injuries. Addressing these factors can enhance risk stratification and inform surgical consent processes.

Review by Burns R, Connor KL (…) Sherif AE et 4 al. in BJS Open

© The Author(s) 2025. Published by Oxford University Press on behalf of BJS Foundation Ltd.

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Postoperative Pancreatic Fistula Rates Climb Amid Racial Disparities

Despite advancements in surgical techniques, the incidence of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy has risen, increasing from 13.3% in 2018 to 15.7% in 2023. Racial disparities impact outcomes, with Asian and other non-White patients facing higher risks. Conversely, preoperative chemotherapy appears to reduce POPF likelihood. This analysis, based on a large cohort of 28,100 patients, underscores a persistent challenge in postoperative care.

Journal Article by Maegawa FB, Tustumi F (…) Nguyen KT et 7 al. in Am J Surg

Copyright © 2025 Elsevier Inc. All rights reserved.

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Acute Pancreatitis Hospitalizations Decline Amid COVID-19 in Japan

In 2021, Japan saw a significant drop in acute pancreatitis (AP) hospitalizations, declining to 61,080 cases from 78,450 in 2016, marking a 49 per 100,000 incidence rate. The mortality rate among severe cases improved to 5.3%, down from 6.1%. Treatment adherence improved; 61.2% of patients received antibiotics and 56.9% of severe cases benefited from enteral nutrition. Importantly, no upfront surgeries were performed, indicating a shift in management strategies during the pandemic.

Journal Article by Tanaka Y, Masamune A (…) Kikuta K et 7 al. in J Gastroenterol

© 2025. The Author(s).

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Long-term Ileal Pouch Surgery Yields Strong Quality of Life

Patients undergoing ileal pouch anal anastomosis (IPAA) report favorable long-term outcomes, with 83% experiencing fewer than seven daily bowel movements and 70% having fewer than two at night. Analysis of 125 patients reveals a median St. Mark’s incontinence score of 5.3, indicating good functional results, and a Cleveland Global Quality of Life score of 18.4, reflecting high quality of life. Overall morbidity stands at 36%, underscoring the procedure’s viability for maintaining sphincter function.

Journal Article by Dammak N, Latifa MB (…) Ali AB et 9 al. in Langenbecks Arch Surg

© 2025. The Author(s).

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New Prognostic Score Predicts Outcomes in HCC Patients

A novel prognostic score effectively stratifies hepatocellular carcinoma patients with microvascular invasion based on early recurrence factors. Evaluating 265 patients, it incorporates serum alpha-fetoprotein levels, hepatitis B e antigen status, and presence of satellite nodules. Higher scores correlate with significantly lower three-year recurrence-free and overall survival rates. The findings underscore the score’s predictive power beyond liver cirrhosis status, providing critical insights for post-hepatectomy patient management.

Journal Article by Li H, Shen J and Wen T in Langenbecks Arch Surg

© 2025. The Author(s).

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Robotic Surgery Outshines Laparoscopy in Colorectal Resections

Robotic assistance during high anterior resections significantly reduces intra-operative blood loss, shortens surgery time, accelerates gastrointestinal recovery, and leads to fewer complications compared to laparoscopic techniques. Patients benefitted from earlier hospital discharge, while oncological outcomes remained comparable. This study offers contemporary insights from a well-established robotic surgery practice, underlining the clinical advantages that robotic systems provide without compromising safety or cancer control.

Comparative Study by Ngu JC, Wong NW (…) Teo NZ et 2 al. in J Robot Surg

© 2025. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.

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Completion of two-stage hepatectomy improves survival outcomes for patients

In a retrospective analysis involving 183 colorectal liver metastasis patients, 69% completed two-stage hepatectomy (tsh), achieving a median overall survival of 65.3 months compared to just 20.6 months for those who failed to complete it. The study identified key prognostic factors linking successful resections to lower rates of extrahepatic disease, tumor size over 5 cm, and better chemotherapy responses. TSH coupled with perioperative systemic therapies significantly enhances long-term outcomes.

Journal Article by Boerner T, Gagnière J (…) D’Angelica MI et 11 al. in Ann Surg

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