Antimicrobial Prophylaxis with Ampicillin-Sulbactam Improves Short-term Outcomes after Esophagectomy

Antimicrobial prophylaxis with ampicillin-sulbactam was found to be more effective compared to cefazolin in reducing surgical site infection, anastomotic leakage, and respiratory failure after esophagectomy. In a study involving 17,772 patients, the use of ampicillin-sulbactam was associated with significantly improved short-term postoperative outcomes, including reduced respiratory complications, length of stay, and total hospitalization costs. No significant differences in noninfectious complications were observed between the two groups.