Antimicrobial prophylaxis with ampicillin-sulbactam was found to be more effective compared to cefazolin in reducing surgical site infection, anastomotic leakage, and respiratory failure after esophagectomy. In a study involving 17,772 patients, the use of ampicillin-sulbactam was associated with significantly improved short-term postoperative outcomes, including reduced respiratory complications, length of stay, and total hospitalization costs. No significant differences in noninfectious complications were observed between the two groups.
Journal Article by Hirano Y, Konishi T (…) Kitagawa Y et 10 al. in Ann Surg
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