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Intestine and Lower Gastrointestinal Tract ·

Distinct Tertiary Lymphoid Patterns in Colorectal Cancer

Deciphering heterogeneous tertiary lymphoid structures (TLS) patterns in colorectal cancer revealed three clusters with different prognostic implications. High metabolic activity and stromal pathways linked to worse outcomes, while immune activation pathways indicated improved prognosis and better response to immunotherapy. A new TLScore based on 9 core genes showed potential for guiding treatment decisions, highlighting the promise of personalized medicine in colorectal cancer.

Journal Article by Lei JX, Wang R (…) Gao F et 8 al. in Int J Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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