Neoadjuvant chemoradiotherapy followed by total mesorectal excision resulted in a 3-year overall survival rate of 84% for patients with T4 and/or N2 rectal adenocarcinoma. Achieving R0 resection improved recurrence and survival rates, with T4 disease showing worse outcomes than N2. Adjuvant chemotherapy was associated with a survival benefit in the whole cohort and the N2 subgroup, but not in the T4 subgroup. Personalizing treatment strategies based on high-risk features could enhance outcomes in locally advanced rectal cancer.
Journal Article by Unrau S, Barthwal M (…) Nashed M et 4 al. in Clin Colorectal Cancer
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