Findings indicate significant differences between insulinomas and non-functional pancreatic neuroendocrine neoplasms (nf-pnens) regarding prognosis and tumor biology. nf-pnens exhibited higher rates of lymph node involvement, perineural invasion, and more advanced tumor grades. The study’s multivariate analysis revealed that nf-pnens with lymph node metastasis and high grading correlated with reduced recurrence-free survival. Genetically, distinct somatic mutations and copy number variations were noted, emphasizing the need for tailored surgical management and follow-up strategies for these neoplasms.
Journal Article by Tan Q, Liu L (…) Wang X et 2 al. in Am J Surg
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