Research highlights two molecular subtypes of gastric cancer, revealing that the stemness subtype substantially increases the risk of hematogenous metastasis (HM). Through analyses of bulk-rna sequencing from 64 samples and a patient-derived xenograft model, the study identified 10 stemness signature genes. These genes helped stratify patients into HM risk groups, demonstrating a notable decrease in hematogenous metastasis-free survival for high-risk individuals across multiple external cohorts, suggesting a pathway for improved predictive models in precision medicine.
Journal Article by Lee S, Yoo J (…) Yang HK et 11 al. in Int J Surg
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