Upper Gastrointestinal Tract · 21 October 2025

Survival Gains with FLOT in cT2cN0 Esophageal Cancer

FLOT chemotherapy significantly improves survival in patients with cT2cN0 adenocarcinoma of the esophagus compared to chemoradiotherapy.

Mean survival: 100.8 months for FLOT vs. 74.6 months for CROSS (p = 0.028).
Three-year survival rates: 87% for FLOT vs. 59% for CROSS.

Surgeons should prioritize FLOT treatment in multimodal approaches for these patients to enhance outcomes.

23.3% of FLOT patients underwent gastrectomy versus 6.8% in the CROSS group (p = 0.007).

Journal Article by Wirsik NM, Schmidt T (…) Bruns CJ et 23 al. in Ann Surg Oncol

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