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Upper Gastrointestinal Tract ·

Multimodal Advances Transforming Gastric Cancer Management

Recent updates in multimodal treatment are reshaping gastric cancer care, impacting surgical strategies and patient outcomes.

  • Laparoscopic and robotic gastrectomy are now standard in Asia, supported by major trials like JCOG0912 and K-LASS02.
  • The FLOT chemotherapy regimen is becoming the global standard, while SOX and XELOX gain traction in Asia.

Surgeons should consider integrating immunotherapy based on emerging trial results for select patients.

  • Ongoing trials are studying the role of conversion surgery in stage IV cases, highlighting the need for personalized multi-disciplinary approaches.

Review by Shoda K, Kawaguchi Y, Maruyama S and Ichikawa D in Ann Gastroenterol Surg

© 2025 The Author(s). Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery.

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