HPB & Spleen · 13 March 2026

Endoscopic Necrosectomy: No Major Differences Found

Upfront endoscopic necrosectomy (UEN) and step-up endoscopic necrosectomy (SUEN) show similar outcomes for walled-off pancreatic necrosis, impacting how you approach patient management.

No significant difference in clinical success (RR: 1.04) or technical success (RR: 1.27) between UEN and SUEN.
Patient safety outcomes, including post-procedural bleeding (RR: 0.66) and recurrence (RR: 0.71), were comparable.

Individualized treatment strategies remain crucial in optimizing patient outcomes.

Average length of hospital stay was nearly identical (SMD: -0.03).

Review by Tazinkeng N, Elmustafa F (…) Igbinedion S et 6 al. in Gastrointest Endosc

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