HPB & Spleen · 30 March 2026

Gallium-68 PET for Pancreatic Neuroendocrine Tumors: Limited Sensitivity

A study shows Gallium-68 DOTATATE PET has high specificity but low sensitivity in identifying lymph node metastases in pancreatic neuroendocrine tumors, affecting surgical decisions.

Detected suspicious lymph nodes in 24% of cases; pathology confirmed involvement in 42%.
Sensitivity was 46%, specificity 92%, with a positive predictive value of 81%.

Consider it for preoperative evaluations, especially for small tumors, keeping in mind its limitations.

Higher Krenning scores and larger lymph nodes correlate with true-positive results.

Journal Article by Gudmundsdottir H, Hernandez-Delima FJ (…) Cleary SP et 7 al. in BMC Surg

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