HPB & Spleen · 29 July 2026

Integrated Response Metrics Enhance Prognosis in CRLM Surgery

Combining anatomical and histologic responses to neoadjuvant therapy improves predicting recurrence in colorectal liver metastases (CRLM) after hepatectomy.

Median recurrence-free survival (RFS) was 15.87 months for 483 patients.
Early recurrence occurred in 36.9%, linked to poor histologic and anatomical responses.

Understanding these combined metrics helps tailor patient selection and surgical planning for better outcomes.

Intrahepatic recurrence was seen in 25.1% of patients, with strong associations to response metrics.

Journal Article by Baldo A, Akabane M (…) Pawlik TM et 15 al. in Ann Surg

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