Robotic-assisted minimally invasive esophagectomy (RAMIE) offers better functional outcomes, reduced morbidity, and improved quality of life compared to traditional open surgery for esophageal cancer without compromising oncological results.

• RAMIE has demonstrated significantly lower overall complications and pain scores, with contemporary mortality rates below 4% and leak rates ranging from 11% to 16%.
• The procedure’s 5-year survival rate stands at 48%, with long-term oncological equivalence to open approaches.

Surgeons at high-volume centers should consider prioritizing RAMIE as a safer, more effective option for eligible patients with locally advanced esophageal cancer.