A multicenter trial demonstrated that radiation-emitting metallic stents (REMS) combined with hepatic arterial infusion chemotherapy (HAIC) significantly outperformed self-expandable metallic stents (SEMS) in patients with unresectable Bismuth type III or IV perihilar cholangiocarcinoma. The median overall survival was 10.2 months for REMS compared to 6.7 months for SEMS (p=0.002). Additionally, median time to symptomatic progression […]
Author: STITCHES Newsletter
In-hospital delays worsen outcomes in acute appendicitis cases
A meta-analysis of 28 studies involving 512,881 patients has revealed that preoperative in-hospital delays exceeding 24 hours significantly increase the risk of complicated appendicitis, postoperative complications, and mortality. Specifically, these delays are associated with a 60% higher risk of complicated appendicitis and a 51% increased likelihood of postoperative issues, alongside an 81% heightened risk of […]
Triple therapy enhances survival in advanced hepatocellular carcinoma.
In high-risk advanced hepatocellular carcinoma patients, triple therapy involving FOLFOX-based hepatic arterial infusion, tyrosine kinase inhibitors, and PD-1 inhibitors significantly improved median overall survival to 24.6 months compared to 11.9 months with dual therapy (HR=0.43, p
New model predicts postpancreatectomy hemorrhage risk accurately
A novel predictive model using lasso-logistic regression has been developed to assess the risk of postpancreatectomy hemorrhage. Analyzing data from over 9,600 patients, the model identifies nine independent risk factors, including preoperative BMI and ASA scores. Its predictive accuracy reached an area under the ROC curve of 0.87 during external validation, outperforming previous models significantly. […]
Delaying surgery post-COVID-19 improves patient outcomes.
A study involving 4,953 patients revealed that delaying surgery for at least two weeks post-COVID-19 infection can significantly lower the risks of short-term complications and mortality. Patients who postponed their procedures for over seven weeks experienced enhanced long-term functional recovery, as indicated by reduced disability rates at both six and twelve months. These findings underline […]
Advances in managing gastric cancer with peritoneal metastasis
Recent insights into gastric cancer with peritoneal metastasis (gcpm) reveal dismal outcomes, underscoring the need for improved management strategies. A growing body of clinical trials investigates the efficacy of cytoreductive surgery (crs) combined with hyperthermic intraperitoneal chemotherapy (hipec), recognized in new national guidelines. Enhanced understanding of gcpm’s mechanisms and novel therapeutic targets could lead to […]
Surgeons benefit from 360-degree feedback on non-technical skills
Feedback from 88 academic surgeons through the intraoperative 360-degree evaluation (i360) primarily highlighted crucial non-technical skills such as leadership and communication. Analysis revealed that 84.3% of comments were related to non-technical skills, with key themes including mentorship, professionalism, teamwork, and situation awareness. Leadership themes accounted for 53.1% of feedback, whereas decision-making and situation awareness were […]
Standardized training for colorectal liver metastases established
A new structured guide addressing colorectal liver metastases (CRLM) fills a vital gap in surgical oncology education. By updating the European Society of Surgical Oncology’s curriculum, it provides essential information on epidemiology, staging, and treatment strategies. Researchers conducted a thorough literature review, focusing on recent guidelines and studies, to support hepatobiliary surgeons and oncologists. This […]
New tool enhances risk prediction for liver surgery complications
A dynamic tool utilizing albumin-bilirubin (ALBI) scores and fibrosis-4 (FIB-4) index trends improves risk stratification for patients undergoing hepatocellular carcinoma resection. K-means clustering revealed three patient groups with varying complication risks. Those in the lowest ALBI cluster had a 76% reduced odds of severe complications compared to the highest-risk group. A novel predictive model achieved […]
Acute pancreatitis incidence and mortality remain significant in England
An analysis of 260,009 acute pancreatitis patients in England from 2013 to 2023 reveals an incidence rate rising by 2.6% annually, with 456 cases per million. In-hospital mortality stands at 4.5%, while the 10-year survival rate reaches 63.9%. Factors influencing better long-term outcomes include biliary etiologies, younger age, and the absence of intensive care unit […]