Co-transplantation of adipose tissue-derived mesenchymal stem cells (ADMSCs) with pancreatic islets into decellularized pancreatic skeletons improved vascularization and preserved islet morphology. While ADMSCs did not suppress immune responses in vivo, their presence reduced the proliferation of splenocytes in vitro. In contrast, endothelial cell co-transplantation resulted in islet-cell necrosis. These findings indicate that ADMSCs are effective […]
Author: STITCHES Newsletter
Probiotics enhance weight loss and eating behavior after surgery
Participants receiving probiotic supplementation alongside a weight loss program and cognitive behavioral therapy experienced significantly greater reductions in weight, body mass index, and fat mass compared to the placebo group (pā
Nomogram effectively predicts liver metastasis in colorectal cancer
A nomogram combining circulating tumor cells (CTC) from the first drainage vein and clinical parameters was developed to predict liver metastasis in colorectal cancer (CRC) patients. Analysis of data from 343 patients revealed that higher CTC levels correlated with liver metastasis. Key identified predictors included vascular invasion, T stage, carcinoembryonic antigen (CEA), and CA19-9. The […]
Minor resections may be preferred for large hepatocellular carcinoma
A multicenter study analyzed 535 patients with single large hepatocellular carcinoma (slhcc). Results indicated that major hepatectomy led to significantly higher major complications and no long-term survival benefits compared to minor resections, especially left lateral sectionectomy, which was associated with better overall survival (p=0.02). The absence of oncological benefits from major resection suggests minor resections […]
Surgical smoke contains multiple infectious viruses.
A systematic review of 26 studies revealed that surgical smoke (ss) harbors various infectious viruses, including human papillomavirus (HPV), HIV, varicella zoster, hepatitis B, SARS-CoV-2, and oral poliovirus. These findings indicate a potential transmission risk to healthcare workers in operating rooms during procedures involving smoke-producing devices. The results emphasize the need for stringent protective measures, […]
Elderly patients experience worse outcomes in acute appendicitis.
Patients aged 65 and older with acute appendicitis presented later, requiring more diagnostic imaging and experiencing higher rates of complications compared to younger adults. The study revealed that elderly individuals had longer symptom durations (7.88 days vs. 3.56 days) and required CT scans more frequently (86.1% vs. 54.0%). Surgical delays were notable, with fewer elderly […]
Gastrectomy achieves long-term survival in advanced pseudomyxoma cases.
Analysis of 120 gastrectomies for appendiceal pseudomyxoma peritonei (PMP) over 20 years revealed a median survival of 104 months and a 10-year overall survival rate of 47%. While complications were observed in 32% of cases, 90-day mortality was low at 1.75%. Outcomes improved over decades, with 82.2% achieving complete cytoreduction (CCR) in the later period, […]
Interval conservative management is safe for incarcerated paraesophageal hernias.
Adopting an initial conservative management strategy for clinically stable patients with incarcerated paraesophageal hernias allows 66% to resolve their conditions without urgent surgery. Among the 35 patients studied, one experienced unplanned readmission before planned interval repair. Complication rates remained similar between those who underwent conservative management and those requiring surgery. Overall, managing these patients conservatively […]
Functional outcomes are comparable in tatme and latme surgeries
A meta-analysis of 11 studies involving 1,020 rectal cancer patients revealed no significant differences in functional outcomes between transanal total mesorectal excision (taTME) and laparoscopic total mesorectal excision (LaTME). Measures of bowel, anorectal, and urogenital function, assessed through various scales like LARS and EORTC QLQ-C30/29, indicated similar results. These findings support the notion that both […]
Prevalence of pouch fistulas post-restorative proctocolectomy is low
A systematic review and meta-analysis of 33 studies revealed a pooled prevalence of pouch fistulas at 0.05, with pouch failure rates in fistula patients at 0.24. The prevalence of developing a pouch fistula at 3, 5, and more than 5 years was similarly low, at 0.04, 0.05, and 0.05, respectively. These findings may guide future […]