Machine learning models were developed utilizing pretreatment magnetic resonance imaging (MRI) radiomics and clinical parameters to predict neoadjuvant chemoradiotherapy response in patients with locally advanced rectal carcinoma. The impact of radiomics dimensionality on predictive performance was assessed. Two models were constructed, revealing moderately advantageous effects of increased dimensionality. These models outperformed the clinical parameter-only model, […]
Author: STITCHES Newsletter
Non-Curative ER for Esophageal Squamous Cell Carcinoma: Long-Term Outcomes and Recurrence Risk with Additional Chemoradiotherapy
Among 97 patients with non-curative endoscopic resection (ER) for esophageal squamous cell carcinoma (ESCC), 73 underwent additional chemoradiotherapy (CRT). With a median follow-up of 71 months, recurrences were observed in 14% of patients. Lymphatic invasion was identified as an independent risk factor for recurrence. Notably, all patients who underwent surgery for recurrent disease survived, regardless […]
CA19-9 is a significant prognostic factor in stage III gastric cancer patients undergoing radical gastrectomy
The main result of this study is that preoperative and postoperative serum CA19-9 values are independent risk factors for predicting the prognosis in patients with stage III gastric cancer after curative gastrectomy. Patients with CA19-9 levels greater than 35 U/ml had significantly lower recurrence-free survival and overall survival rates compared to those with CA19-9 levels […]
Improved neoadjuvant and adjuvant therapy needed for biliary tract cancer
Neoadjuvant and adjuvant therapy for biliary tract cancer (BTC) have shown limited success in improving outcomes for patients. This review highlights that while a minority of BTC patients are eligible for curative surgery, their survival rates remain poor with high recurrence rates. The study evaluates current clinical trials and identifies challenges and limitations in their […]
Low-volume Ambulatory Surgery Centers Linked to Higher Revisit Rates, especially for Multimorbid Patients
The study assessed the association between surgical volume and patient outcomes in ambulatory surgery centers (ASCs). It found that patients who had surgery at low-volume ASCs had a higher odds of revisiting within 7 days compared to those at higher-volume ASCs. This association was more pronounced among patients with multimorbidity, particularly those undergoing orthopedic procedures. […]
Selective Lateral Pelvic Lymph Node Dissection After Preoperative Chemoradiotherapy in Middle/Low Rectal Cancer
Selective lateral pelvic lymph node dissection after preoperative chemoradiotherapy has been found to decrease local recurrence in middle/low rectal cancer, providing survival benefits. The study investigated the safety, indications, and survival benefits of this procedure based on preoperative characteristics. Results showed that surgery times were significantly prolonged by preoperative chemoradiotherapy, and poor/mucinous/signet-ring adenocarcinoma and postchemoradiotherapy […]
Sodium thiosulfate effectively prevents cisplatin-induced nephrotoxicity in patients undergoing cytoreductive surgery with HIPEC
Sodium thiosulfate can effectively prevent cisplatin-induced nephrotoxicity in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), eliminating the need for preoperative intravenous hyperhydration. A retrospective analysis of 220 patients showed that the use of sodium thiosulfate significantly reduced serum creatinine levels and preserved glomerular filtration rate compared to hyperhydration alone or in combination with […]
Non-Thermal Plasma accelerates wound healing in abdominal surgeries
Non-Thermal Plasma (NTP) therapy was evaluated as a method to speed up wound healing in patients who underwent laparoscopic and open abdominal surgeries. Researchers used a needle-type reactor with an irradiance of 0.5 w/cm² to apply NTP. The pilot study showed promising results, indicating that NTP therapy can be efficacious and safe in enhancing recovery […]
Perioperative and long-term survival outcomes of pancreatectomy with arterial resection in pancreatic cancer
Despite the involvement of major arteries in pancreatic cancer, pancreatectomy with arterial resection (AR) following neoadjuvant therapy (NAT) can potentially enhance survival rates. A systematic review and meta-analysis of nine retrospective studies, with a total sample size of 215, showed that pancreatectomy with AR achieved an overall R0 resection rate of 79%. The median 1-, […]
Shift from Laparoscopic to Robot-assisted Minimally Invasive Pancreatoduodenectomy in Europe
The first 3 years of the E-MIPS registry revealed acceptable morbidity and mortality rates after minimally invasive pancreatoduodenectomy (MIPD) in Europe. The study included 1,336 patients who underwent MIPD, with 835 robot-assisted and 501 laparoscopic procedures. The rate of centers performing laparoscopic MIPD decreased from 46.9% to 25%, while robot-assisted MIPD increased from 46.9% to […]