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Use of pegsitacianine, a pH-sensitive imaging agent, detected residual disease in 50% of patients undergoing cytoreductive surgery. Pegsitacianine showed high sensitivity, improved surgeon assessment, and had acceptable safety profile. This agent has the potential to enhance detection of residual disease and improve outcomes in peritoneal…
Hyperthermic intraperitoneal chemotherapy (HIPEC) significantly improved overall survival and reduced recurrence rates in both prophylactic and therapeutic settings for peritoneal carcinomatosis of gastric origin. This systematic review and meta-analysis of randomized trials highlights the efficacy of HIPEC as a safe and effective tool for prophylaxis…
Mucinous and non-mucinous appendiceal adenocarcinomas exhibit differences in recurrence rates and nodal positivity. Colectomy is associated with improved disease-specific survival for non-mucinous tumors at certain stages and grades, but not for mucinous tumors. This suggests that colectomy may not be necessary for mucinous appendiceal adenocarcinoma…
Development and testing of a prototype deep learning surgical guidance system showed improved performance in identifying peritoneal surface metastases compared to oncologic surgeons. The system demonstrated potential for increasing identification of metastases by 5% and reducing unnecessary biopsies by 28% in a simulated clinical environment.
The study showed that simultaneous resection of liver metastases combined with HIPEC resulted in a significantly higher complete resection rate, total effective rate, and negative change of CEA compared to resection alone. This approach demonstrated superior efficacy in treating synchronous colorectal cancer liver metastases, potentially…
Centralization of cytoreductive surgery alone for colorectal peritoneal metastases improved 90-day postoperative mortality and failure-to-rescue rates. High-volume centers showed lower mortality rates compared to low-volume and no-hipec centers. After the Prodige 7 trial, there was a drastic decrease in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy…
Patients with colorectal peritoneal metastases who underwent cytoreductive surgery had better disease-free and overall survival if they had a dominant pushing histological growth pattern compared to infiltrating pattern. The study confirmed the prognostic value of these patterns regardless of neoadjuvant chemotherapy or extent of peritoneal…
Enhanced Recovery After Surgery (ERAS) protocol implementation for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) led to increased epidural use, decreased oral and intravenous opioid requirements, and earlier restoration of bowel function. Patients with epidurals had significantly lower opioid needs post-ERAS, with improved ambulation, diet…
Findings from a nationwide population-based study revealed that patients diagnosed in hipec centers had better odds of undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) and improved survival rates before 2016. However, after national efforts to increase awareness and improve referral networks, these differences were…
Laparoscopic HIPEC for gastric cancer with peritoneal metastasis is safe and associated with minimal perioperative complications. Approximately one third of patients undergoing initial laparoscopic HIPEC proceeded to cytoreduction and gastrectomy. Preliminary survival data from this study indicate a median overall survival of 11 months from…
