International experts in pancreatic surgery and cancer management developed and validated guidelines for the perioperative care of patients with borderline resectable (BR) and locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). The guidelines include 34 recommendations covering patient selection, timing of surgery, vascular reconstruction, lymphadenectomy, and more. Despite a low level of evidence for most clinical […]

Researchers found that postoperative day 3 and day 5 C-reactive protein levels have high predictive value for detecting liver resection-surgical site infections, with optimal cut-off values identified. This information can assist in ruling out infections and making decisions regarding hospital discharge in patients undergoing liver resection. Journal Article by Pattou M, Fuks D (…) Tzedakis […]

Early drain removal (EDR) after pancreaticoduodenectomy (PD) is superior to late drain removal (LDR) in reducing major morbidity and shortening length of stay. While the difference in postoperative pancreatic fistula rates was not statistically significant, EDR showed lower rates of major morbidity and shorter length of stay. These findings suggest that EDR can lead to […]

Short-term postoperative outcomes of lymphadenectomy for cholangiocarcinoma, hepatocellular carcinoma, and colorectal liver metastases were analyzed in 3456 patients undergoing liver resection. Lymphadenectomy was performed in 16% of cases, with the highest rate seen in robotic-assisted resections. However, it was associated with an increased risk of liver-specific postoperative complications, particularly in patients with hepatocellular carcinoma. These […]

Adjuvant chemotherapy (AC) shows a significant survival advantage in patients with resected gallbladder adenocarcinoma, according to a retrospective cohort analysis. Factors like age, tumor grade, and stage were identified as independent prognostic factors. Poor/undifferentiated tumor histology, higher tumor stage, and lymph node involvement were also associated with improved survival with AC. These findings support the […]

Laparoscopic radical antegrade modular pancreatosplenectomy (RAMPS) showed significantly higher rates of R0 resection (91.7% vs. 69.2%) and similar intraoperative blood loss and operative time compared to laparoscopic distal pancreatectomy with splenectomy. Both procedures had similar perioperative complication rates. The study demonstrates that laparoscopic RAMPS is a safe and feasible approach with improved oncological outcomes for […]

Pancreatic ductal adenocarcinoma patients exhibit varied responses to therapy, with molecular subtyping revealing classical and basal-like subtypes, the latter associated with poorer outcomes. Two main tumor subtypes were identified, along with high-risk stromal subtypes linked to worse survival. Superior survival was seen with classical subtype. Despite challenges in cost and data volume, molecular subtyping can […]

Unplanned conversion during laparoscopic liver resection for hepatocellular carcinoma is associated with higher blood loss, transfusion rate, hospital stay, and postoperative complications. However, the 5-year overall survival rate was similar in patients who underwent unplanned conversion and those who underwent laparoscopic liver resection. Journal Article by Lee B, Cho JY (…) Kim J et 5 […]

After left pancreatectomy for pancreatic adenocarcinoma, patients with a perioperative platelet count ratio (PPR) ≥ 1.5 had significantly longer median overall survival (OS) compared to those with PPR < 1.5 (40 months vs. 20 months). PPR was identified as a biomarker for predicting long-term survival in these patients, suggesting its potential as a prognostic factor […]