A systematic review of eleven studies indicates curative-intent surgery for hepato-pancreato-biliary (HPB) cancers can yield statistically significant cures. Hepatocellular carcinoma showed cure fractions of 63.4% to 75.8% with liver transplantation and 31.8% to 40.5% with hepatic resection. Intrahepatic cholangiocarcinoma demonstrated a cure fraction of 9.7% based on tumor stage, while pancreatic neuroendocrine tumors and pancreatic […]

A modified dosing protocol (MDP) for hepatic arterial infusion (HAI) with reduced floxuridine starting dose resulted in fewer dose holds and reductions compared to the standard dosing protocol (SDP). MDP patients completed more cycles before dose reduction, received more overall cycles, and had fewer instances of treatment-ending biliary toxicity. Conversion to hepatic resection was similar […]

Bifurcated allogeneic vein grafts significantly reduce sinistral portal hypertension (SPH) in pancreatic carcinoma patients post-pancreaticoduodenectomy with spleno-mesenterico-portal (SMP) confluence resection. Retrospective analysis showed a lower SPH incidence in the reconstruction group (8.1% vs. 36.4%). Prospective data supported this, with only 6.7% SPH in patients undergoing splenic vein reconstruction. Key indicators like platelet count, spleen volume, […]

Triple therapy with folfox-based hepatic arterial infusion chemotherapy, tyrosine kinase inhibitors, and PD-1 inhibitors significantly prolonged overall survival (24.6 vs 11.9 months) and progression-free survival (10.0 vs 7.7 months) compared to dual therapy. The triple-therapy group also had higher response rates and more patients converted to non-high-risk status, showcasing its potential as a first-line treatment […]

In a comparison of laparoscopic (LPD) versus open (OPD) pancreaticoduodenectomy for ampullary cancer, LPD showed longer operative times but less blood loss and shorter hospital stays. No significant differences were found in morbidity, survival rates, or recurrence-free survival between LPD and OPD. Both approaches had comparable short- and long-term outcomes. Despite fewer lymph nodes harvested […]

Robotic warshaw procedure (r-wp) demonstrated superiority over laparoscopic (l-wp) in reducing postoperative splenic infarction incidence, despite longer operative times. Among 33 cases analyzed, r-wp completed procedures laparoscopically, while l-wp required open conversion in 8.7% cases. Although r-wp showed prolonged surgery duration (421 vs. 300 min), blood loss was comparable (19 vs. 20 ml). Notably, l-wp […]

Researchers found that the lymphocyte-to-monocyte ratio (LMR) is a significant predictor of cancer-specific survival (CSS) in patients with intraductal papillary mucinous neoplasm with associated invasive carcinoma (IPMN-Inv). An LMR higher than 3.5 was linked to better CSS, with a hazard ratio (HR) of 0.305 in univariate and 0.221 in multivariate analyses. Other prognostic factors included […]

Advanced surgical planning and intraoperative hepatic vein guidance with a cranio-caudal approach facilitates safe and complex laparoscopic liver resections, leading to successful outcomes with minimal complications. Operative time was 360 min with 450 ml blood loss, and the patient was discharged on the seventh postoperative day. Pathological examination confirmed R0 resection, with necrosis of liver […]

Robotic liver parenchymal transection using the SynchroSeal demonstrated superior outcomes compared to the Vessel Sealer, with lower blood loss (48 ml vs 95 ml) and similar perioperative results. The SynchroSeal led to low conversion rates, minimal blood loss, short hospital stays, and acceptable morbidity. This analysis highlights the safety and effectiveness of the SynchroSeal for liver surgery, […]