In a study of 282 patients with borderline resectable pancreatic cancer, those undergoing neoadjuvant treatment (NAT) followed by surgery exhibited the best overall survival (OS) of 35 months compared to 23 months for upfront surgery and 16 months for chemotherapy only. Patients receiving at least 3 months of NAT showed significantly improved OS, while those […]

Evidence from a multi-institutional cohort study indicates that adjuvant therapy significantly improves overall survival rates in patients with high-risk periampullary adenocarcinomas. Among 736 patients analyzed, those receiving adjuvant therapy had a median overall survival of 68.7 months compared to 61.1 months for those under observation, translating to a hazard ratio of 0.73. Additionally, nodal involvement […]

A comparison of distal pancreatectomies across North America and Europe revealed that minimally invasive techniques were performed in 36% of cases, varying from 29% to 54% among regions. This approach demonstrated significantly lower 30-day mortality (odds ratio 1.633) and fewer severe complications in North America and Germany compared to open surgery. Notable patient demographic differences […]

Elevated-risk patients for pancreatic ductal adenocarcinoma (PDAC) who underwent guideline-based screening achieved significantly improved overall survival compared to non-screened counterparts. Among 826 patients, those in the high-risk clinic experienced longer median survival rates, with 68% diagnosed at stage 0 versus 31% in the surgical oncology group. Overall survival post-resection was also notably higher in high-risk […]

With a remarkable 0% conversion and mortality rate, the “easy first” technique for laparoscopic hepatic caudate lobectomy has shown promise in safety and effectiveness. By employing sextet strategies—meticulous planning, optimal trocar placement, and efficient team positioning—clinicians can tackle the complexities of the caudate lobe. The study emphasizes the necessity of proper patient selection and advanced […]

A retrospective analysis of 25,848 pancreaticoduodenectomy patients revealed that 10.5% had preoperative hypoalbuminemia, which significantly correlated with increased 30-day complications. Specifically, hypoalbuminemic patients faced higher risks for serious complications (OR 1.80) independent of other comorbidities but did not have increased mortality risk (OR 1.37). The median age of hypoalbuminemic patients was notably higher, and many […]

The two-parts wrapping technique significantly reduces postoperative pancreatic fistula (POPF) and postpancreatectomy hemorrhage (PPH) in laparoscopic pancreaticoduodenectomy (LPD). Analyzing data from 172 patients, researchers found lower rates of overall and severe complications, particularly in patients with soft pancreatic textures and smaller duct diameters. Notably, the two-parts wrapping group experienced no instances of severe PPH and […]

Enhanced overall survival (27.0 months) and progression-free survival (8.0 months) were observed in the HAIC-len-p group compared to the len-p alone group (9.0 months and 3.0 months, respectively, p

A systematic review of eleven studies indicates curative-intent surgery for hepato-pancreato-biliary (HPB) cancers can yield statistically significant cures. Hepatocellular carcinoma showed cure fractions of 63.4% to 75.8% with liver transplantation and 31.8% to 40.5% with hepatic resection. Intrahepatic cholangiocarcinoma demonstrated a cure fraction of 9.7% based on tumor stage, while pancreatic neuroendocrine tumors and pancreatic […]