Establishing preoperative chemotherapy (PCT) with FOLFIRINOX and gemcitabine/nab-paclitaxel enabled resectability in 61.2% of 139 patients with initially unresectable locally advanced pancreatic cancer. PCT did not increase perioperative mortality or morbidity, with 92.9% achieving R0 resection. Median postoperative survival was 31 months, highlighting the significant potential of PCT in extending recurrence-free and overall survival for resected […]

Laparoscopic surgery shows improved survival rates, less bleeding, shorter hospital stays, and lower complication rates compared to open surgery for gallbladder cancer. However, concerns remain due to factors like incidental cancer, heterogeneity, publication bias, and lymph node dissection. Subgroup analyses suggest ethnicity, sample size, and follow-up duration as potential sources of variability. Further research is […]

Patients with hepatocellular carcinoma undergoing major hepatectomy had higher complication rates and shorter recurrence-free survival compared to those undergoing minor hepatectomy, regardless of propensity score matching. Major hepatectomy was identified as an independent predictor for HCC recurrence. Minor hepatectomy resulted in fewer postoperative complications and better recurrence-free survival outcomes. Therefore, parenchyma-sparing resection should be favored […]

Primary suturing after microincision of the cystic duct confluence is safe and effective for treating CBD stones in patients with a normal CBD diameter. A retrospective study on 104 patients with gallstone complications showed no significant differences in perioperative outcomes between normal and dilated CBD groups, with no biliary tract injuries or laparotomy conversions. This […]

Preoperative biliary drainage method significantly impacts outcomes in patients with biliary tract and pancreatic cancer undergoing pancreaticoduodenectomy. Higher morbidity rates were observed with endoscopic biliary drainage methods compared to percutaneous drainage. Percutaneous drainage was associated with worse disease-free survival in biliary tract cancer but did not affect outcomes in pancreatic cancer. Lower albumin levels were […]

Patients with pancreatic neuroendocrine tumors face a 20% risk of disease recurrence or metastasis post-pancreatectomy, with prognostic factors like larger tumor size, high ki-67 index, perineural invasion, and node-positive disease significantly impacting disease-free survival. Non-functional tumors are more prevalent, with 2-year and 5-year disease-free survival rates at 82% and 76%, respectively. Identifying these predictors can […]

Minimally invasive liver surgery (MILS) has doubled in incidence from 2013 to 2022, now representing 25.2% of liver resections in France. Major liver resections, primary, and secondary malignant tumors show the highest annual increases. University hospitals and high-volume centers are leading the adoption of MILS. Conversely, open liver surgery rates are decreasing across all indications […]

Analysis of American College of Surgeons data revealed a 1.98% 30-day mortality rate in patients undergoing pancreatoduodenectomy according to International Study Group of Pancreatic Surgery criteria. Postoperative pancreatic fistula (POPF) correlated with higher complications, readmission, and mortality rates, with males at higher risk than females (57.42% vs. 47.35%). Female sex was a protective factor against […]