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A new lasso-logistic regression model was developed and validated, identifying nine independent risk factors for postpancreatectomy hemorrhage among 9,631 patients across two cohorts. The model demonstrated strong predictive accuracy, achieving an area under the receiver operating characteristic curve of 0.87 during external validation, significantly outperforming…
In a study of 282 patients with borderline resectable pancreatic cancer, those undergoing neoadjuvant treatment (NAT) followed by surgery exhibited the best overall survival (OS) of 35 months compared to 23 months for upfront surgery and 16 months for chemotherapy only. Patients receiving at least…
Evidence from a multi-institutional cohort study indicates that adjuvant therapy significantly improves overall survival rates in patients with high-risk periampullary adenocarcinomas. Among 736 patients analyzed, those receiving adjuvant therapy had a median overall survival of 68.7 months compared to 61.1 months for those under observation,…
A comparison of distal pancreatectomies across North America and Europe revealed that minimally invasive techniques were performed in 36% of cases, varying from 29% to 54% among regions. This approach demonstrated significantly lower 30-day mortality (odds ratio 1.633) and fewer severe complications in North America…
Development and validation of the ISGPP model marks a significant advancement in automating residual pancreatic cancer (RPC) quantification. The model demonstrated robust performance across diverse scanners, achieving mean F1 scores of 0.81-0.71 upon validation. A comprehensive dataset of 528 unique H&E slides from 528 patients…
Elevated-risk patients for pancreatic ductal adenocarcinoma (PDAC) who underwent guideline-based screening achieved significantly improved overall survival compared to non-screened counterparts. Among 826 patients, those in the high-risk clinic experienced longer median survival rates, with 68% diagnosed at stage 0 versus 31% in the surgical oncology…
With a remarkable 0% conversion and mortality rate, the "easy first" technique for laparoscopic hepatic caudate lobectomy has shown promise in safety and effectiveness. By employing sextet strategies—meticulous planning, optimal trocar placement, and efficient team positioning—clinicians can tackle the complexities of the caudate lobe. The…
A retrospective analysis of 25,848 pancreaticoduodenectomy patients revealed that 10.5% had preoperative hypoalbuminemia, which significantly correlated with increased 30-day complications. Specifically, hypoalbuminemic patients faced higher risks for serious complications (OR 1.80) independent of other comorbidities but did not have increased mortality risk (OR 1.37). The…
The two-parts wrapping technique significantly reduces postoperative pancreatic fistula (POPF) and postpancreatectomy hemorrhage (PPH) in laparoscopic pancreaticoduodenectomy (LPD). Analyzing data from 172 patients, researchers found lower rates of overall and severe complications, particularly in patients with soft pancreatic textures and smaller duct diameters. Notably, the…
Enhanced overall survival (27.0 months) and progression-free survival (8.0 months) were observed in the HAIC-len-p group compared to the len-p alone group (9.0 months and 3.0 months, respectively, p
