Category: HPB & Spleen

High Fat Content Linked to Poor Outcomes in Liver Surgery Patients

Patients with high intramuscular fat content (IMFC) or high visceral-to-subcutaneous fat tissue ratio (VSR) undergoing hepatectomy or liver transplantation had significantly worse overall survival, recurrence-free survival, and higher major complication rates. A meta-analysis of 29 articles including 6,435 patients revealed that IMFC was associated with inferior outcomes and a higher risk of complications, while VSR […]

Neoadjuvant Chemoradiotherapy Shows Improved Outcomes in Pancreatic Cancer

Neoadjuvant chemoradiotherapy followed by surgery demonstrates enhanced overall survival (OS) rates compared to upfront surgery and neoadjuvant chemotherapy in patients with resectable and borderline resectable pancreatic cancer. This approach also increases margin-negative resection rates and pathological negative lymph node rates. However, it carries a higher risk of grade 3 or higher treatment-related adverse events, particularly […]

Histological Predictors of Aggressive HCC Recurrence

Histological features such as microvascular invasion and/or satellitosis were strong predictors of aggressive recurrence and mortality in hepatocellular carcinoma patients post-liver resection. A retrospective study of 218 patients revealed that the presence of these features was the only independent risk factor for aggressive recurrence, exceeding Milan criteria and poorer survival outcomes. Patients with these histological […]

Task division in robotic pancreaticoduodenectomy improves outcomes and education

Task division by multiple console surgeons in robotic pancreaticoduodenectomy significantly reduced operation time and postoperative complications compared to a single console surgeon approach. Despite less experienced surgeons, the turnover between resection and reconstruction led to safer pancreatojejunostomy. Surgeons adopting the multiple approach observed early benefits with reduced surgical time and fewer complications, highlighting the potential […]

Large duct-type ICCA shows worse survival rates and unique genetic features

Large duct-type ICCA exhibits worse overall and recurrence-free survival rates compared to small duct-type ICCA. Mutational landscape analysis revealed distinct genetic alterations, with specific mutations in ARID1A, DOT1L, and ELF3 more common in large duct-type ICCA, while mutations in IDH1 and BAP1 were prevalent in small duct-type ICCA. The overexpression of PPP1R1B in large duct-type […]

High Incidence of Aberrant Hepatic Artery in Patients with Hepatocellular Carcinoma

Aberrant hepatic artery is common in patients with hepatocellular carcinoma, with complex variations impacting treatment. A retrospective study of 1250 patients showed a high incidence of aberrant hepatic artery (21.3%), affecting operation duration and postoperative outcomes. Variations included aberrant left and right hepatic artery origins. Differences in tace operation duration, nausea, vomiting, and laboratory results […]