The course of the segment 4 hepatic artery affects the proximal ductal margin status in right hepatectomy for perihilar cholangiocarcinoma. The study found that the l-up type of the artery, running along the left cranial position of the umbilical portion of the left portal vein, was associated with a higher rate of negative proximal ductal […]
Category: HPB & Spleen
Adjuvant chemotherapy improves overall survival in resected stage I pancreatic cancer
A meta-analysis of six comparative studies involving 6,874 patients with resected stage I pancreatic cancer revealed that adjuvant chemotherapy is associated with significantly higher overall survival and 2-year survival rates compared to surgery alone. However, there was no statistically significant difference in 1-year, 3-year, or 5-year survival rates. This study suggests that adjuvant chemotherapy may […]
ERCP in Palestine: Comparable to international standards with low complication rates
The study evaluated the utilization and outcomes of endoscopic retrograde cholangiopancreatography (ERCP) procedures in the first advanced endoscopy center in Palestine. A total of 1909 procedures on 1303 patients were included, with an overall complication rate of 5%. The primary adverse events were post-ERCP pancreatitis (2.3%), infection/cholangitis (1%), bleeding (0.5%), and perforation (0.4%). Risk factors […]
Rising HCC Hospitalizations and Decreased Mortality Highlight Financial Burden
The study analyzed trends in hospitalizations for hepatocellular carcinoma (HCC) in the United States between 2011 and 2017. The researchers found an increase in HCC-related admissions over the years, with a decrease in inpatient mortality rates. However, there was a significant rise in the financial burden on healthcare due to increasing hospital charges and longer […]
Neoadjuvant Chemotherapy Increases Risk of Postoperative DVT in Distal Pancreatectomy for Pancreatic Adenocarcinoma
Patients with pancreatic adenocarcinoma who undergo distal pancreatectomy and receive neoadjuvant chemotherapy (NAT) are 73% more likely to develop postoperative deep venous thrombosis (DVT) compared to those who undergo upfront resection. This association is significant and highlights the need to prioritize high-risk patients for extended duration prophylaxis. The study analyzed data from 4327 patients using […]
Precision Surgery Shows Promise for Colorectal Liver Metastases with Mutras Tumors
Patients with mutras colorectal liver metastases (crlm) may benefit from anatomic resection (AR) compared to nonanatomic resection (NAR), according to a systematic review and meta-analysis. The study found that AR was associated with a significant improvement in liver-specific disease-free survival and overall disease-free survival among patients with mutras tumors, but not among those with wild-type […]
Delta Radiomic Features Predict Resection Margin and Survival in Pancreatic Cancer after Neoadjuvant Treatment
The study demonstrates that delta radiomic features (DRFs), when combined with clinical variables, are effective in predicting resection margin status (RMS) and overall survival (OS) in neoadjuvant-treated pancreatic cancer patients. The models outperform clinical feature-based and other radiomics feature-based models in predicting OS, disease-free survival (DFS), and RMS. These externally validated, predictive/prognostic DRF models provide […]
Cholangitis and interruptions of neoadjuvant chemotherapy decrease survival in pancreatic cancer
Patients with pancreatic cancer who experience cholangitis have reduced overall survival (OS) and progression-free survival (PFS). Interrupting neoadjuvant chemotherapy (NAT) also decreases OS and PFS. Biliary decompression with metallic stents reduces the rate of chemotherapy interruptions and cholangitis compared to plastic stents. However, the choice of stent type does not affect OS or PFS. This […]
Early Prediction of PHLF: Clinical Risk Factors Outperform Lactate Levels
The study aimed to compare the accuracy of prediction models in detecting clinically relevant post-hepatectomy liver failure (PHLF) following major hepatectomy. The researchers evaluated the use of arterial lactate measurements as an early predictor of PHLF in a subgroup of major hepatectomies, finding that lactate levels on postoperative day 1 were inferior to clinical risk […]
Local Therapy Improves Survival for Early Recurrence After Resection of Colorectal Liver Metastases
A study evaluated whether local therapy benefits patients who experience early recurrence after hepatectomy for colorectal liver metastases (CLM). Clinicopathologic data of 671 patients were analyzed, with 81% experiencing recurrence. Local therapy, including ablation, resection, or radiation, resulted in improved survival for patients with early, intermediate, or later recurrence. Treatment with local therapy, liver and […]