Unresectable pancreatic cancer, with a bleak 5-year survival rate of 13.3%, has prompted a shift from traditional surgical interventions to innovative minimally invasive techniques. Researchers detail the evolution from open surgeries to procedures like endoscopic stent placement and percutaneous biliary drainage, improving patient quality of life. Advances such as lumen-apposing metal stents are facilitating key […]

A consensus of 43 international experts has established the Brescia PERIPAN guidelines to address inconsistencies in diagnosing neoplasms near the ampulla of Vater. The comprehensive recommendations encompass enhanced anatomical definitions, refine tumor classifications, and improve pathology assessment protocols. By clarifying distinctions between ampullary and other periampullary tumors, this initiative aims to elevate patient care and […]

Robotic right anterior sectionectomy, utilizing the extrahepatic glissonean approach and indocyanine green (ICG) fluorescence, demonstrates significant advancements in minimally invasive liver surgery. The use of the da Vinci Xi system enabled enhanced dexterity and visualization, which optimized the dissection of the glissonean pedicle and improved surgical precision. Key benefits included minimized remnant ischemia and reduced […]

An international multicenter study established the first global benchmarks for robotic liver resections (r-lr), analyzing 1,654 cases across 24 expert centers. Key outcome indicators for low-risk procedures were defined, revealing operation times ranging from 190 to 474 minutes and zero 90-day mortality. The study highlights benchmarks for operation time, conversion rates, estimated blood loss, blood […]

A new preoperative model effectively predicts lymphovascular invasion (LVI) in patients with pancreatic ductal adenocarcinoma (PDAC). Utilizing data from 1,009 patients across three hospitals, researchers identified key high-risk predictors such as age under 65, cachexia, and specific imaging findings. Their nomogram outperformed expectations, demonstrating strong predictive capability in both development and validation cohorts. High-risk patients […]

Implementing Enhanced Recovery After Surgery (ERAS) pathways significantly improves patient outcomes following pancreatic surgeries. A study of 220 patients revealed that those in the ERAS group experienced markedly reduced postoperative opioid use (58 vs. 148 mg) and lower pain scores (6 vs. 8). Moreover, the ERAS cohort demonstrated a lower overall complication rate, particularly in […]

Evidence from a comprehensive meta-analysis reveals that surgical intervention dramatically outperforms nonsurgical management for pancreatic neuroendocrine tumors. With a pooled hazard ratio for mortality of 0.30, surgical patients showed better survival rates at one, three, five, and ten years compared to their nonsurgical counterparts. While surgical options are paramount for resectable tumors, nonsurgical management remains […]

Post-surgical analysis reveals men experience significantly worse recurrence-free survival after liver resection for HCC and ICC compared to women, with 5-year rates of 30.0% versus 43.9% and 18.7% versus 26.8%, respectively. Male murine models also showed larger tumor recurrences linked to increased immunosuppressive cells. The male-specific SRY gene promotes an immunosuppressive microenvironment, implicating potential targeted […]

Researchers found that jejunal limb decompression (JLD) significantly lowers the incidence of early-onset postoperative cholangitis in patients undergoing pancreaticoduodenectomy. In a study involving 281 patients, the incidence dropped from 20.7% to 1.7% when JLD was employed. Additionally, a drainage volume of ≥1555 ml within 14 days post-surgery was identified as an independent risk factor for […]